The modulation of venlafaxine on cortical activation of language area in healthy subjects with fMRI study.

Psychopharmacology
Qi XieHong-Min Bai

Abstract

Previous studies have shown that selective serotonin reuptake inhibitors, activators of the cortex, apparently improved language functional recovery after brain damage rather than simply affective disorders. Our aim was to determine whether venlafaxine (an agonist of both norepinephrine and 5-hydroxytryptamine) could modulate language cortex function. A double-blind, crossover, randomized design was used to compare two 7-day treatment sessions with either venlafaxine (75 mg per day) or placebo. A functional magnetic resonance imaging experiment and two language function tests were performed on eight healthy males (mean age, 28.25 ± 3.15 years) at the end of each session, i.e., study entry, after venlafaxine, and after placebo (days 0, 7, and 18). Hyperactivation (venlafaxine minus placebo >0) or hypoactivation (placebo minus venlafaxine >0) by venlaxafine was assessed on the basis of the activation-baseline contrast. The naming score (P < .001) and spontaneous language fluency (P < .001) were significantly higher after venlafaxine than after placebo. Functional magnetic resonance imaging (fMRI) showed that (1) picture naming activated the left posterior gyrus frontalis medius and the bilateral fusiform gyrus and the bilateral o...Continue Reading

References

Jul 1, 1989·Trends in Neurosciences·S A Lipton, S B Kater
Mar 1, 1985·Brain and Language·S E Kohn, H Goodglass
Jun 1, 1997·Trends in Neurosciences·P LevittE H Murphy
May 23, 1998·NeuroImage·T J GrabowskiA R Damasio
Sep 3, 1999·Journal of Cognitive Neuroscience·S MurthaA Evans
Nov 5, 1999·Stroke; a Journal of Cerebral Circulation·Y CaoK M Welch
Apr 19, 2000·Journal of Cognitive Neuroscience·R Cabeza, L Nyberg
Sep 8, 2001·Stroke; a Journal of Cerebral Circulation·D Walker-BatsonD H Unwin
Dec 26, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R S DumanJ Malberg
Jan 10, 2002·Annals of Neurology·Cathrin M BütefischLeonardo G Cohen
Oct 3, 2002·Annual Review of Psychology·Morton Ann Gernsbacher, Michael P Kaschak
Oct 3, 2002·Annual Review of Psychology·Randi C Martin
Jun 5, 2003·International Journal of Psychiatry in Medicine·Stefanie A HorsfieldStephen I Deutsch
Jul 26, 2003·NeuroImage·Cathy J Price, Joseph T Devlin
Nov 18, 2003·Nature Reviews. Neuroscience·Patricia GasparLuc Maroteaux
Jul 21, 2004·Cognitive, Affective & Behavioral Neuroscience·Irene P Kan, Sharon L Thompson-Schill
Aug 7, 2004·Stroke; a Journal of Cerebral Circulation·Bruno FernandezMichèle Allard
Sep 18, 2004·Trends in Neurosciences·Mark P MattsonBronwen Martin
Apr 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cristina M Del-BenIan M Anderson
Jan 1, 1997·Expert Opinion on Investigational Drugs·E SchweizerA Frazer
Dec 14, 2005·NeuroImage·Andrea MechelliCathy J Price
Sep 20, 2006·Brain and Language·Xavier de BoissezonJean-François Démonet
Mar 6, 2007·Brain : a Journal of Neurology·Jessica DeLeonArgye E Hillis
Sep 18, 2007·Psychopharmacology·Patrice PéranDominique Cardebat
May 19, 2009·Behavioural Brain Research·Gor Sarkisyan, Peter B Hedlund

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Citations

Dec 10, 2013·Journal of Clinical Psychopharmacology·Chun-yong LiYan Liu

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