The modulatory cholinergic system in goldfish tectum may be necessary for retinotopic sharpening

Visual Neuroscience
J T Schmidt

Abstract

The cholinergic circuit within the tectum and the cholinergic input from the nucleus isthmi mediate a presynaptic augmentation of retinotectal transmitter release via nicotinic receptors. In this study, the cholinergic systems were either eliminated using the cholinergic neurotoxin AF64A or blocked using nicotinic antagonists to test for effects on the activity-driven sharpening of the regenerating retinotectal projection. The effectiveness of the AF64A was verified by recording field potentials elicited by optic tract stimulation and by immunohistochemical staining for choline acetyltransferase (ChAT). At 1 week after intracranial (IC) injection of AF64A (12 to 144 nmoles) into the fluid above the tectum, field potentials showed a selective dose-dependent decrement of the cholinergic polysynaptic component with no effect on the amplitude of the glutamatergic monosynaptic component. The decrement was only partially recovered in recordings at 2 and 6 weeks. In normal fish, the ChAT antibody stains a population of periventricular neurons, their apical dendrites, and a dense plexus within the optic terminal lamina that consists of their local axons and fine dendrites and of input fibers from the nucleus isthmi. One week after IC A...Continue Reading

References

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Jan 1, 1980·Acta Neuropathologica·J A Kiernan, A Contestabile

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Citations

Jun 7, 2005·General and Comparative Endocrinology·Susan B Udin
Jun 26, 2001·Brain Research. Brain Research Reviews·S Thanos, J Mey
Aug 27, 1999·Progress in Neurobiology·S B Udin, S Grant
Feb 28, 2002·Current Opinion in Neurobiology·Elizabeth A Debski, Hollis T Cline
Sep 23, 2008·Journal of Chemical Neuroanatomy·Rosa M Giraldez-PerezRosario Pasaro
Apr 3, 2003·The European Journal of Neuroscience·Chuan-Jiang YuElizabeth A Debski

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