PMID: 2497512Apr 1, 1989Paper

The modulatory effect of lipoproteins on the release of interleukin 1 by human peritoneal macrophages stimulated with beta-1,3-D-polyglucose derivatives

Scandinavian Journal of Immunology
L T Rasmussen, R Seljelid

Abstract

Human peritoneal macrophages were stimulated in vitro with beta-1,3-D-polyglucose-derivatized microbeads (GDM) or soluble aminated beta-1,3-D-polyglucose (AG) in combination with lipoproteins. The release of interleukin 1 (IL-1) was analysed in cell supernatants in a thymocyte proliferation assay. We report that the release of IL-1 is markedly enhanced in macrophages stimulated with polyglucose in either form in combination with native low-density lipoprotein (LDL) or acetyl LDL at a concentration of 100 micrograms/ml. By increasing the amount of lipoproteins up to 10-fold, the IL-1 release decreased sharply. There was only a slight increase in activity when high-density lipoprotein (HDL) or very low-density lipoprotein (VLDL) were added. Other stimulatory agents, such as gamma interferon (IFN-gamma) and lipopolysaccharide (LPS) showed about half the activity of polyglucose. There was no significant difference between native LDL and acetyl LDL in potentiating effect. Our observations also suggest that the potentiating effect of LDL or acetyl LDL is not dependent on binding to their specific receptors. These findings provide a connection between macrophages, lipoproteins, and cytokines with regard to their role in the inflammato...Continue Reading

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Citations

Jan 1, 1993·Cytotechnology·K Bertheussen
Feb 1, 1990·Journal of in Vitro Fertilization and Embryo Transfer : IVF·N HolstH I Nielsen
Feb 1, 1992·International Journal of Immunopharmacology·E K GallinM L Patchen
Feb 24, 2015·World Journal of Experimental Medicine·Valter Lubrano, Silvana Balzan
Aug 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·J GaleaC M Holt
Nov 1, 1993·European Journal of Haematology·R Seljelid, T Eskeland

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