The Modulatory Effect of Metabotropic Glutamate Receptor Type-1α on Spike-Wave Discharges in WAG/Rij Rats

Molecular Neurobiology
F KarimzadehA Gorji

Abstract

Modulatory function of metabotropic glutamate type 1 (mGlu1) receptors plays a crucial role in the pathophysiology of some neurological disorders, including schizophrenia and epilepsy. In this study, the expression of mGlu1α receptors in the thalamic nuclei was assessed during development of absence seizures in the WAG/Rij rats, a valid genetic animal model of absence epilepsy. In addition, the effect of pharmacological modulation of mGlu1α receptors in the laterodorsal (LD) nucleus of the thalamus on the characteristic features of bioelectrical brain activities in the WAG/Rij rats was assessed. The expression of mGlu1α receptors in the LD was assessed in four experimental groups of both WAG/Rij and Wistar rats with 2 and 6 months of age. Agonist and antagonist of mGlu1α receptors were infused in LD in the six months old WAG/Rij (epileptic) rats. The protein level of mGlu1α receptors in the thalamus of the 6-month-old WAG/Rij rats was lower than non-epileptic animals. In addition, the distribution of mGlu1α receptors in different thalamic nuclei was lower in the 6-month-old WAG/Rij compared to age-matched Wistar rats. The gene expression of mGlu1α receptor was also significantly lower in 6-month-old WAG/Rij rats in the LD compa...Continue Reading

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Citations

Apr 5, 2017·Cephalalgia : an International Journal of Headache·Amir GhaemiAli Gorji
Jan 23, 2019·Journal of Cellular Physiology·Fatemeh SaffarzadehFariba Karimzadeh
Feb 26, 2019·Expert Opinion on Therapeutic Targets·Roberta CelliFerdinando Nicoletti
May 20, 2021·Neurochemical Research·Mitra Barzroodi PourFariba Karimzadeh

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Methods Mentioned

BETA
electrophoresis
X-ray
PCR

Software Mentioned

Image J

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