The molecular and gene/miRNA expression profiles of radioiodine resistant papillary thyroid cancer.

Journal of Experimental & Clinical Cancer Research : CR
Carla ColomboMaria Grazia Borrello

Abstract

Papillary thyroid cancer (PTC) is the most frequent endocrine tumor. Radioiodine (RAI) treatment is highly effective in these tumors, but up to 60% of metastatic cases become RAI-refractory. Scanty data are available on either the molecular pattern of radioiodine refractory papillary thyroid cancers (PTC) or the mechanisms responsible for RAI resistance. We analyzed the molecular profile and gene/miRNA expression in primary PTCs, synchronous and RAI-refractory lymph node metastases (LNMs) in correlation to RAI avidity or refractoriness. We classified patients as RAI+/D+ (RAI uptake/disease persistence), RAI-/D+ (absent RAI uptake/disease persistence), and RAI+/D- (RAI uptake/disease remission), and analyzed the molecular and gene/miRNA profiles, and the expression of thyroid differentiation (TD) related genes. A different molecular profile according to the RAI class was observed: BRAFV600E cases were more frequent in RAI-/D+ (P = 0.032), and fusion genes in RAI+/D+ cases. RAI+/D- patients were less frequently pTERT mutations positive, and more frequently wild type for the tested mutations/fusions. Expression profiles clearly distinguished PTC from normal thyroid. On the other hand, in refractory cases (RAI+/D+ and RAI-/D+) no d...Continue Reading

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Citations

Feb 13, 2021·International Journal of Molecular Sciences·Stanislaw SupplittIzabela Laczmanska
Jun 3, 2021·International Journal of Molecular Sciences·Elisa BonaldiEmanuela Minna

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Datasets Mentioned

BETA
GSE27155

Methods Mentioned

BETA
Assay
RNAseq

Software Mentioned

GenePattern
MedCalc
limma
MedCalc Analyses
CIBERSORT
ComplexHeatmap

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