The Molecular Basis and Therapeutic Potential of Let-7 MicroRNAs against Colorectal Cancer

Canadian Journal of Gastroenterology & Hepatology
Rei MizunoYoshiharu Sakai

Abstract

Although a number of studies have revealed the underlying mechanisms which regulate the development of colorectal cancer (CRC), we have not completely overcome this disease yet. Accumulating evidence has shown that the posttranscriptional regulation by the noncoding RNAs such as microRNAs plays an important role in the development or progression of CRC. Among a number of microRNAs, the let-7 microRNA family that was first discovered in C. elegans and conserved from worms to humans has been linked with the development of many types of cancers including CRC. The expression level of let-7 microRNAs is temporally low during the normal developmental processes, while elevated in the differentiated tissues. The let-7 microRNAs regulate the cell proliferation, cell cycle, apoptosis, metabolism, and stemness. In CRC, expressions of let-7 microRNAs have been reported to be reduced, and so let-7 microRNAs are considered to be a tumor suppressor. In this review, we discuss the mechanisms regulating the let-7 microRNA expression and the downstream targets of let-7 in the context of intestinal tumorigenesis. The application of let-7 mimics is also highlighted as a novel therapeutic agent.

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Citations

Apr 23, 2019·Journal of Oncology·Duncan AyersManuel Macías-González
Jun 27, 2019·Veterinary Clinical Pathology·Janne G LyngbySusanna Cirera
Apr 29, 2020·International Journal of Molecular Sciences·Siran ZhuGracjan Michlewski
Mar 21, 2020·Cell Death Discovery·Massimiliano AgostiniGerry Melino
Nov 23, 2019·Pharmacology & Therapeutics·Sona VodenkovaVeronika Vymetalkova
Jul 6, 2020·Human Antibodies·Nahal EshghifarFarkhondeh Pouresmaeili
Dec 8, 2020·Translational Oncology·Stephen J O'BrienSusan Galandiuk
Feb 11, 2021·Cell Death Discovery·Massimiliano AgostiniGerry Melino
Jun 15, 2020·Pharmacology & Therapeutics·Aditi DasHannah C Huff
Apr 17, 2021·Essays in Biochemistry·Huiwen Yan, Pengcheng Bu
Apr 29, 2021·Scientific Reports·Joshua Miguel C Danac, Reynaldo L Garcia
May 29, 2021·OncoTargets and Therapy·Lingling YeQuan An Zhang
Jul 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Abolfazl AkbariShahram Agah
Jul 4, 2021·The Journal of Investigative Dermatology·Evelyn KelemenMárta Széll

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Methods Mentioned

BETA
transgenic
xenografts
xenograft

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