The molecular basis for the assembly and modulation of adherens-type junctions

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

The molecular basis for the assembly and modulation of adherens-type junctions

Abstract

References

Reversion from transformed to normal phenotype by inhibition of protein synthesis in rat kidney cells infected with a temperature-sensitive mutant of Rous sarcoma virus

Changes in microfilament organization and surface topogrophy upon transformation of chick embryo fibroblasts with Rous sarcoma virus

Novel function for beta 1 integrins in keratinocyte cell-cell interactions

The role of integrins alpha 2 beta 1 and alpha 3 beta 1 in cell-cell and cell-substrate adhesion of human epidermal cells

Cleavage of A-CAM by endogenous proteinases in cultured lens cells and in developing chick embryos

Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells

An epithelium-type cytoskeleton in a glial cell: astrocytes of amphibian optic nerves contain cytokeratin filaments and are connected by desmosomes.

Identification of two distinct functional domains on vinculin involved in its association with focal contacts

Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts

Adhesion molecule mapping in normal human skin

Uvomorulin-catenin complex: cytoplasmic anchorage of a Ca2+-dependent cell adhesion molecule.

Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion

Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton

A-CAM: a 135-kD receptor of intercellular adherens junctions. II. Antibody-mediated modulation of junction formation

Spatial and temporal relationships between vinculin and talin in the developing chicken gizzard smooth muscle

Molecular interactions in adherens-type contacts

ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells

A-CAM: a 135-kD receptor of intercellular adherens junctions. I. Immunoelectron microscopic localization and biochemical studies

Biochemical characterization of the soluble form of the junctional plaque protein, plakoglobin, from different cell types

Spatial and temporal expression pattern of N-cadherin cell adhesion molecules correlated with morphogenetic processes of chicken embryos

Molecular heterogeneity of adherens junctions

Contact-inhibited revertant cell lines isolated from SV 40-transformed cells. IV. Microfilament distribution and cell shape in untransformed, transformed, and revertant Balb-c 3T3 cells

Adhesion plaques of Rous sarcoma virus-transformed cells contain the src gene product

Actin-independent association of vinculin with the cytoplasmic aspect of the plasma membrane in cell-contact areas

Mobility of microinjected rhodamine actin within living chicken gizzard cells determined by fluorescence photobleaching recovery

Citations

Comparison between the in vivo and in vitro expression of three adhesion-signaling proteins in embryonic cells

Focal adhesion as a signal transduction organelle

Molecular biology of cadherins in the nervous system

Ultrasound inhibits the adhesion and migration of smooth muscle cells in vitro

Expression of a midgut-specific cadherin BT-R1 during the development of Manduca sexta larva

Suppression of tumorigenicity in simian virus 40-transformed 3T3 cells transfected with alpha-actinin cDNA

Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies.

Suppression of tumorigenicity in transformed cells after transfection with vinculin cDNA

Restricted tissue distribution of a 37-kD possible adherens junction protein

Suppression of vinculin expression by antisense transfection confers changes in cell morphology, motility, and anchorage-dependent growth of 3T3 cells

Contractile activity and cell-cell contact regulate myofibrillar organization in cultured cardiac myocytes

Differential localization and sequence analysis of capping protein beta-subunit isoforms of vertebrates.

A talin homologue of Dictyostelium rapidly assembles at the leading edge of cells in response to chemoattractant

Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin

The protein tyrosine kinase p56lck regulates cell adhesion mediated by CD4 and major histocompatibility complex class II proteins

Direct involvement of N-cadherin-mediated signaling in muscle differentiation

LI-cadherin: a marker of gastric metaplasia and neoplasia

Signaling to the actin cytoskeleton

Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice

Changing distribution of cadherins during gestation in the uterine epithelium of lizards

Polysialylated NCAM represses E-cadherin-mediated cell-cell adhesion in pancreatic tumor cells

Construction of a high-resolution physical map of the chromosome 10q22-q23 dilated cardiomyopathy locus and analysis of candidate genes

Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation

Overexpression of vinculin suppresses cell motility in BALB/c 3T3 cells

Cell-adhesion to crystal surfaces. Adhesion-induced physiological cell death

The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells.

Morphogenesis of the avian trunk neural crest: use of morphological techniques in elucidating the process

Evidence for a ternary interaction between alpha-actinin, (meta)vinculin and acidic-phospholipid bilayers

Latrunculin B Reduces Intraocular Pressure in Human Ocular Hypertension and Primary Open-Angle Glaucoma.

Tyrosine phosphorylation of the novel protein-tyrosine kinase RAFTK during an early phase of platelet activation by an integrin glycoprotein IIb-IIIa-independent mechanism.

Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL.

E-cadherin and catenins: molecules with versatile roles in normal and neoplastic epithelial cell biology

nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP).

Vinculin gene is non-essential in Drosophila melanogaster

Human skeletal muscle-specific alpha-actinin-2 and -3 isoforms form homodimers and heterodimers in vitro and in vivo

Untangling desmosomal knots with electron tomography

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