The molecular basis of adrenocortical cancer

Cancer Genetics
Tomasz Lehmann, Tomasz Wrzesinski

Abstract

Adrenocortical tumors (ACTs) are common, and most are benign adrenocortical adenomas (ACAs). Malignant adrenocortical carcinoma (ACC) is a rare tumor type and is observed at the rate of one or two cases per million annually. ACTs are classified as either ACAs or ACCs by histopathologic methods that are based on nine Weiss scoring criteria, including the nuclear grade, mitotic rate, presence of necrosis, and others. In this review, we describe the findings of studies that have examined the molecular basis of ACTs, and we compare transcriptome analysis with other diagnostic approaches. ACTs are occasionally difficult to classify. Therefore, molecular techniques, such as microarray analysis, have recently been applied to overcome some of these diagnostic problems. We also discuss the likelihood of the diagnosis and discernment between ACAs and ACCs based on the molecular tests. To show the recent progress in understanding the etiology of ACTs, we highlight the relationship between genetic analysis and transcriptome analysis. We attempt to understand the role of abnormal cell growth and steroid hormone secretion. Genetic and transcriptome analyses have improved our understanding of ACTs considerably, yet many unanswered questions r...Continue Reading

References

Jan 1, 1992·Genes, Chromosomes & Cancer·C Caron de Fromentel, T Soussi
Feb 22, 1991·Cell·T M DeChiaraA Efstratiadis
Apr 5, 1989·Journal of the National Cancer Institute·T YanoB Zbar
Mar 1, 1984·The American Journal of Surgical Pathology·L M Weiss
Aug 1, 1995·European Journal of Endocrinology·C GicquelY Le Bouc
May 15, 1995·Cancer·A A Kasperlik-ZałuskaA M Makowska
Nov 16, 1994·Journal of the National Cancer Institute·J WagnerD Malkin
Feb 1, 1994·The Journal of Clinical Endocrinology and Metabolism·S R LinJ H Tsai
Sep 1, 1993·The Journal of Clinical Endocrinology and Metabolism·V IlvesmäkiR Voutilainen
Sep 1, 1997·The Journal of Clinical Endocrinology and Metabolism·M ReinckeB Allolio
Sep 16, 1999·American Journal of Human Genetics·J M VarleyJ M Birch
Feb 25, 2000·Current Opinion in Oncology·N N Hanna, D E Kenady
Jul 17, 2001·European Journal of Endocrinology·L BarzonM Boscaro
Nov 30, 2002·European Journal of Endocrinology·F FalloJ M Mathis
Jan 28, 2003·The American Journal of Pathology·Thomas J GiordanoSamir M Hanash
Mar 5, 2003·Annals of Internal Medicine·Melvin M GrumbachH Samuel Wieand
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Liangying LuHironobu Sasano
Apr 12, 2005·American Journal of Surgery·William S CobbB Todd Heniford
Jun 30, 2005·The Journal of Clinical Endocrinology and Metabolism·Mary H BassettWilliam E Rainey
Oct 20, 2005·The Journal of Clinical Endocrinology and Metabolism·Lawrence S Kirschner
Dec 8, 2005·The Journal of Clinical Endocrinology and Metabolism·Karla Saner-AmighWilliam E Rainey
Dec 20, 2005·Surgery·David Velázquez-FernándezMartin Bäckdahl
Mar 25, 2006·European Journal of Endocrinology·E P SlaterD K Bartsch
May 9, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·C P LombardiR Bellantone
Jan 11, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S SchinnerW A Scherbaum
Jan 20, 2007·Cancer Research·Alina Nico WestGerard P Zambetti
Mar 31, 2007·Endocrine-related Cancer·Rossella LibèJérôme Bertherat
Jan 14, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aurélien de ReynièsJérôme Bertherat
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas J GiordanoGary Hammer
May 5, 2009·European Journal of Endocrinology·Cecilia LaurellMartin Bäckdahl
Jun 9, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Martin Fassnacht, Bruno Allolio
Nov 26, 2010·Molecular and Cellular Endocrinology·Abeer El Wakil, Enzo Lalli
Dec 21, 2010·Seminars in Oncology·Massimo MannelliGabriele Parenti
Jan 21, 2011·European Journal of Endocrinology·Tao WangWilliam E Rainey
Apr 12, 2011·Journal of Surgical Oncology·Frederick L BaehnerMichael T Barrett

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Citations

Apr 19, 2013·Cancer Metastasis Reviews·Joshua B StevensHenry H Heng
Dec 18, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Diana Rita SzabóPeter Igaz
Jun 6, 2014·Endocrine-related Cancer·Sandra Rodríguez-RoderoMario F Fraga
Nov 5, 2015·Cancer Investigation·Beatrice RubinFranco Mantero
Dec 7, 2013·Clinical Endocrinology·Yunze XuYiran Huang
Mar 30, 2016·Current Problems in Diagnostic Radiology·Larson D HsuToshimasa J Clark
Aug 1, 2014·Journal of Clinical Pathology·J S RossP J Stephens
Feb 5, 2014·Nature Reviews. Endocrinology·Guillaume AssiéJérôme Bertherat
Jan 31, 2016·Clinical Nuclear Medicine·Ka Kit WongMilton D Gross
Jul 8, 2016·Expert Review of Proteomics·Hye Min KimJa Seung Koo
Feb 25, 2019·Current Oncology Reports·Sina Jasim, Mouhammed Amir Habra
Aug 6, 2019·Endocrine·Sofia S PereiraDuarte Pignatelli
Apr 27, 2021·Expert Opinion on Emerging Drugs·Vineeth SukrithanBhavana Konda
Oct 31, 2020·Journal of Pediatric Hematology/oncology·Connor T A BrennaDavid Malkin

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