PMID: 9448909Feb 4, 1998Paper

The molecular basis of intractable diarrhoea of infancy

Baillière's Clinical Gastroenterology
S H Murch

Abstract

The intractable diarrhoeas of infancy present very major problems of clinical management. However, the conceptual importance of these conditions lies in the information that they may provide about normal small-intestinal function in humans: among such infants will be found the human equivalents of the 'knock-out' mice, in which targeted gene disruption allows sometimes unexpected insight into the regulation of intestinal function. The challenge posed by the intractable diarrhoeal syndromes, of working backwards from an apparently common phenotype to probably multiple genotypes, is, however, immense. Very few of these conditions have been described at the genetic level, although the molecular basis of pathogenesis has been better explored in recent years. The two major groups of intractable diarrhoea are due to (1) primary epithelial abnormalities (which usually present within the first few days of life) and (2) immunologically mediated (which generally present after the first few weeks). The high prevalence of autoimmune enteropathy among infantile autoimmune disease, in contrast to adult autoimmunity, is intriguing and may reflect constitutive abnormality of extrathymic lymphocyte maturation. The use of potent immunosuppressiv...Continue Reading

References

May 1, 1992·Journal of Pediatric Gastroenterology and Nutrition·A D Phillips, J Schmitz
Mar 1, 1991·Archives of Disease in Childhood·I R SandersonJ A Walker-Smith
Dec 1, 1990·The Journal of Pediatrics·E G SeidmanC C Roy
Apr 1, 1988·The Journal of Experimental Medicine·T T MacDonald, J Spencer
Nov 1, 1986·British Medical Journal·R MirakianG F Bottazzo
Feb 1, 1988·Clinical Science·A D PhillipsJ A Walker-Smith
Nov 3, 1988·The New England Journal of Medicine·B AlarconC Terhorst
Jan 1, 1986·Journal of Pediatric Gastroenterology and Nutrition·A JonasS Avigad
Dec 1, 1985·Journal of Pediatric Gastroenterology and Nutrition·L CarruthersJ A Walker-Smith
Mar 1, 1984·Archives of Disease in Childhood·P I Macfarlane, V Miller
May 1, 1982·The Journal of Pediatrics·B R PowellP Stenzel
Jan 1, 1982·Journal of Pediatric Gastroenterology and Nutrition·J UnsworthJ Walker-Smith
Nov 1, 1995·Immunology Today·A Fischer, A Arnaiz-Villena
Nov 1, 1995·Immunology Today·M Murakami, T Honjo
Aug 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E J Kovacs, L A DiPietro
Oct 1, 1995·Gastroenterology·R M SchwartzM D Levitt
Oct 1, 1995·Human Pathology·L MooreA Ferrante
Jun 1, 1995·FEMS Immunology and Medical Microbiology·G GrantN C Garber
Jul 1, 1995·Immunity·G A HolländerC Terhorst
Aug 1, 1995·The Journal of Pediatrics·O GouletN Cerf-Bensussan
Dec 1, 1994·Alimentary Pharmacology & Therapeutics·R M BeattieJ A Walker-Smith
Mar 1, 1995·Journal of Gastroenterology and Hepatology·S H Murch
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·J P DiSantoK Rajewsky
Aug 7, 1993·Lancet·J M Martín-VillaA Arnaiz-Villena

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Citations

Oct 24, 1998·Nutrition·J A Walker-Smith
Sep 4, 2003·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·E Bernardos, J A Solís-Herruzo
Feb 29, 2008·Orphanet Journal of Rare Diseases·Olivier GouletJean-Pierre Cézard
Mar 5, 2010·Acta Paediatrica·E SavilahtiM Verkasalo
Jun 26, 2002·Journal of Pediatric Gastroenterology and Nutrition·Simon H Murch
Jul 29, 2003·Journal of Pediatric Gastroenterology and Nutrition·Alfredo GuarinoUNKNOWN Italian National Network for Pediatric Intestinal Failure
Apr 16, 1999·Journal of Pediatric Gastroenterology and Nutrition·S H MurchJ A Walker-Smith
Apr 5, 2000·Journal of Pediatric Gastroenterology and Nutrition·N C Pirisi-HauckS Kurunczi

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