PMID: 9428608Jan 15, 1998Paper

The molecular basis of rheumatoid arthritis

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
C M Weyand, J J Goronzy

Abstract

Rheumatoid arthritis (RA) is an inflammatory disease targeting the synovial membrane and extra-articular tissues. The most feared consequences are significant levels of pain, functional disability, and rheumatoid organ involvement. Molecular investigations of RA have markedly changed the understanding of the pathogenesis although the etiology remains unresolved. Despite the failure of intense efforts to confirm the presence of an infectious micro-organism in rheumatoid synovium, the concept that RA is infectious in origin has continued to be attractive. Theories on the autoimmune nature of RA have benefited from the enormous progress made in understanding the cellular and molecular components of normal immune responses. However, convincing experimental evidence of a joint-specific endogenous antigen in the synovial lesions is still lacking. The viewpoint that RA represents the sequelae of systemic lymphoproliferation has recently been supported by the finding of autoreactive T cells with atypical growth and differentiation behavior. Significant cross-fertilization for the understanding of RA can be expected by studies elucidating cell cycle control and the role of proto-oncogenes. The realization that RA is a genetic disease ha...Continue Reading

Citations

Feb 1, 2002·European Journal of Pharmacology·Kazumi UrakawaYasuhisa Takeda
May 26, 1999·Survey of Ophthalmology·E M Messmer, C S Foster
Jun 27, 2003·Human Immunology·Maria Francisca González-EscribanoAntonio Núñez-Roldán
Nov 6, 2002·Journal of Cellular and Molecular Medicine·Andra BalanescuDenisa Predeteanu
Dec 21, 2006·Annals of the Rheumatic Diseases·Mohamed M ThabetT W J Huizinga
Nov 13, 2001·Clinical and Experimental Immunology·K MigitaK Eguchi
Nov 25, 2000·Clinical and Experimental Immunology·H TaubertD Riemann
Sep 26, 2007·Annals of the New York Academy of Sciences·Rossana ScrivoGuido Valesini
Jul 8, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Mahendra Kumar Verma, Kota Sobha
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T NamekawaJ J Goronzy
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael A CremerAndrew H Kang

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