PMID: 4895220Mar 1, 1969Paper

The molecular basis of suppression in an ochre suppressor strain possessing altered ribosomes

Proceedings of the National Academy of Sciences of the United States of America
T K GartnerP Reid

Abstract

Escherichia coli K12 2320(lambda)-15B has a mutation that results in ochre suppressor activity.(1) This mutation concomitantly causes a decreased growth rate in rich medium, an increased sensitivity to streptomycin,(1) and the production of some altered 30S ribosomes which are differentially sensitive to RNase.(2) The results presented below demonstrate that the molecules which cause suppression are tRNA. These observations justify the conclusions that the suppressor mutation did not occur in a structural gene for a ribosomal component, and that the decreased growth rate in rich medium, the increased sensitivity to streptomycin, and the production of altered 30S ribosomes are probably all secondary consequences of the suppressor mutation.

References

Jan 1, 1966·Cold Spring Harbor Symposia on Quantitative Biology·J D SmithS Brenner
Jan 1, 1966·Cold Spring Harbor Symposia on Quantitative Biology·J CarbonC Yanofsky
Dec 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·D L EngelhardtN Zinder
Nov 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·R F GestelandA Bolle
Oct 8, 1965·Biochemical and Biophysical Research Communications·P J ReidT K Gartner
Oct 14, 1967·Journal of Molecular Biology·R E WebsterW Konigsberg
Jan 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·T K GARTNER, E ORIAS
Jun 1, 1965·Journal of Molecular Biology·G W NOTANIN D ZINDER

❮ Previous
Next ❯

Citations

Mar 1, 1972·Journal of Bacteriology·E OriasM Betlach

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.