The molecular basis of the host response to lipopolysaccharide.

Nature Reviews. Microbiology
Clare E BryantNicholas J Gay

Abstract

Lipopolysaccharide (LPS), which is produced by Gram-negative bacteria, is a powerful activator of innate immune responses. LPS binds to the proteins Toll-like receptor 4 (TLR4) and MD2 to activate pro-inflammatory signalling pathways. The TLR4-MD2 receptor complex is crucial for the host recognition of Gram-negative bacterial infection, and pathogens have devised many strategies to evade or manipulate TLR4-MD2 activity. The TLR4-MD2 signalling pathway is therefore potentially an important therapeutic target. This Progress article focuses on recent exciting data that have revealed the structural basis of TLR4-MD2 recognition of LPS.

References

Sep 21, 1990·Science·R R SchumannR J Ulevitch
Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·C A Janeway
Apr 7, 1995·Science·W J ChristM A Mullarkey
Feb 17, 1999·The Journal of Experimental Medicine·S T QureshiD Malo
Jun 8, 1999·The Journal of Experimental Medicine·R ShimazuM Kimoto
Jun 3, 2000·Nature Genetics·N C ArbourD A Schwartz
Jan 21, 2001·The Journal of Biological Chemistry·Y OkamuraJ F Strauss
May 9, 2002·Archives of Internal Medicine·Eva LorenzDavid A Schwartz
Jun 5, 2002·Annual Review of Biochemistry·Christian R H Raetz, Chris Whitfield
Jun 11, 2002·Nature Immunology·Yoshinori NagaiKensuke Miyake
Jun 22, 2002·Trends in Biochemical Sciences·Naohiro Inohara, Gabriel Nuñez
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Maureen MullarkeyDaniel P Rossignol
Oct 23, 2003·The Journal of Biological Chemistry·Axel G StöverRobert M Hershberg
Dec 6, 2003·Pharmacological Reviews·Richard R NeubigUNKNOWN International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification
Mar 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Theresa L GioanniniJerrold P Weiss
Jul 28, 2004·Trends in Biochemical Sciences·Monique Gangloff, Nicholas J Gay
Dec 21, 2004·Nature Reviews. Microbiology·Samuel I MillerMartin W Bader
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Athmane TeghanemtTheresa L Gioannini
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Apr 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daniel C RoweDouglas T Golenbock
Jun 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Anne F McGettrickLuke A J O'Neill
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Prasad RallabhandiStefanie N Vogel
Aug 19, 2006·Nature Reviews. Immunology·Nicholas J GayAlexander N R Weber
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vladimir Y ToshchakovStefanie N Vogel
Mar 17, 2007·Annual Review of Biochemistry·Nicholas J Gay, Monique Gangloff
Mar 17, 2007·Biochemical and Biophysical Research Communications·Lieh Yoon LowJaime Pascual
Apr 26, 2007·Nature Reviews. Immunology·Luke A J O'Neill, Andrew G Bowie
Jun 16, 2007·Science·Verónica Mata-HaroThomas C Mitchell
Dec 12, 2007·Handbook of Experimental Pharmacology·Nicholas J Gay, Monique Gangloff
Dec 19, 2007·Infection and Immunity·Robert S Munford

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Citations

Feb 3, 2011·Hepatology International·João-Bruno SoaresAdelino Leite-Moreira
Oct 8, 2011·Biochimica Et Biophysica Acta·Md Munan ShaikLaura Cendron
Oct 9, 2012·Nature Structural & Molecular Biology·Louis E MetzgerRobert M Stroud
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sung-il YoonIan A Wilson
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Eugene ValkovBostjan Kobe
Jun 23, 2012·Open Biology·Clare E Bryant, Tom P Monie
Jul 6, 2013·Veterinary Research·Katherine Lucy IrvineClare Elizabeth Bryant
Aug 2, 2012·Journal of Biomedical Science·Ching-Hua HsiehJohnson Chia-Shen Yang
Mar 4, 2014·Annual Review of Biochemistry·Chris Whitfield, M Stephen Trent
Dec 15, 2010·International Journal of Microbiology·Andreas F HaagGail P Ferguson
Jan 19, 2011·Veterinary Immunology and Immunopathology·Maria TaraktsoglouDavid E MacHugh
Apr 11, 2015·Critical Reviews in Biochemistry and Molecular Biology·Clare E BryantKim S Midwood
Jun 16, 2015·Frontiers in Microbiology·Eyal Dor-On, Beka Solomon
Oct 24, 2014·Frontiers in Immunology·Ardiyanto Liaunardy-Jopeace, Nicholas J Gay
Feb 15, 2015·Developmental and Comparative Immunology·Sergio CandelVictoriano Mulero
Aug 18, 2012·PloS One·Charles N RudickDavid J Klumpp
Jul 14, 2010·Behavioural Brain Research·Javier Leonardo Rodríguez RicoSilvio Morato
Apr 22, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Margarita PetropoulouPenelope C Ioannou
Feb 22, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Tao DingHaiyan Hu
Feb 11, 2018·Molecular Neurobiology·Federica FrigerioChristophe Bernard
Oct 13, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Jun-Pyo ChoiYou Sook Cho
Apr 11, 2017·Nature Structural & Molecular Biology·Qingshan LuoYihua Huang
Apr 19, 2015·Microbial Cell Factories·Uwe MamatRonald Wesley Woodard
Dec 10, 2015·Scientific Reports·Teresa ParamoPeter J Bond
Mar 7, 2012·Biotechnology Letters·Axel HollmannAnderson Miyoshi
Aug 1, 2015·Protoplasma·Noelia Pastor-CantizanoFernando Aniento
Sep 13, 2011·Archives of Microbiology·Balasubramanian VigneshkumarKrishnaswamy Balamurugan
Nov 1, 2011·Journal of Molecular Recognition : JMR·Bart W Bardoel, Jos A G Strijp

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