The Molecular Biology of HIV Latency

Advances in Experimental Medicine and Biology
Georges KhouryCarine Van Lint

Abstract

HIV remains incurable due to the existence of a reservoir of cells that harbor intact integrated genomes of the virus in the absence of viral replication. This population of infected cells remains invisible to the immune system and is not targeted by the drugs used in the current antiretroviral therapies (cART). Reversal of latency by the use of inhibitors of chromatin-remodeling enzymes has been studied extensively in an attempt to purge this reservoir of latent HIV but has thus far not shown any success in clinical trials. The full complexity of latent HIV infection has still not been appreciated, and the gaps in knowledge prevent development of adequate small-molecule compounds that can effectively perturb this reservoir. In this review, we will examine the role of epigenetic silencing of HIV transcription, posttranscriptional regulation, and mRNA processing in promoting HIV-1 latency.

Citations

Jul 18, 2020·Current Opinion in HIV and AIDS·Jesper Damsgaard GunstOle Schmeltz Søgaard
Oct 17, 2019·Frontiers in Immunology·Gilles DarcisAlexander O Pasternak
Nov 28, 2018·Nature Microbiology·Carine Van Lint
Nov 12, 2019·Frontiers in Cellular and Infection Microbiology·Clementine WalletChristian Schwartz
Sep 26, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Livio AzzoniLuis J Montaner
Oct 4, 2020·Microorganisms·Antonio Victor Campos CoelhoSergio Crovella
Apr 9, 2020·Frontiers in Microbiology·Anthony R MeleMichael R Nonnemacher
Mar 12, 2020·Frontiers in Cellular and Infection Microbiology·David Ajasin, Eliseo A Eugenin
May 6, 2020·Viruses·Rayhane NchiouaFrank Kirchhoff
Nov 5, 2019·Frontiers in Immunology·Amanda B MacedoAlberto Bosque
Sep 2, 2019·Current Opinion in Virology·Alex OlsonAndrew J Henderson
Feb 10, 2021·Viruses·Antonio Victor Campos CoelhoLucas André Cavalcanti Brandão
Nov 14, 2020·Viruses·Koh Fujinaga, Daniele C Cary
Aug 28, 2021·Cells·Isabel PaganiElisa Vicenzi
Jan 2, 2022·Stem Cell Reviews and Reports·K KallmeyerM S Pepper

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