The molecular biology of vestibular schwannomas and its association with hearing loss: a review.

Genetics Research International
Erika Celis-AguilarJuan A Rey

Abstract

Hearing loss is the most common symptom in patients with vestibular schwannoma (VS). In the past, compressive mechanisms caused by the tumoral mass and its growth have been regarded as the most likely causes of the hearing loss associated with VS. Interestingly, new evidence proposes molecular mechanisms as an explanation for such hearing loss. Among the molecular mechanisms proposed are methylation of TP73, negative expression of cyclin D1, expression of B7-H1, increased expression of the platelet-derived growth factor A, underexpression of PEX5L, RAD54B, and PSMAL, and overexpression of CEA. Many molecular mechanisms are involved in vestibular schwannoma development; we review some of these mechanisms with special emphasis on hearing loss associated with vestibular schwannoma.

References

Mar 1, 1990·Cancer Genetics and Cytogenetics·J CouturierG Thomas
Nov 15, 1989·International Journal of Cancer. Journal International Du Cancer·J R Teyssier, D Ferre
Sep 1, 1987·Cancer Genetics and Cytogenetics·J A ReyS Moreno
Oct 1, 1983·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·N RasmussenM Tos
Apr 1, 1993·Genes, Chromosomes & Cancer·M J BelloJ A Rey
Sep 6, 1996·American Journal of Medical Genetics·M E BaserS M Pulst
Apr 1, 1997·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R M IrvingE R Maher
Apr 18, 1998·Human Molecular Genetics·D H GutmannS Saporito-Irwin
Nov 18, 1998·Human Molecular Genetics·J Zucman-RossiG Thomas
May 18, 1999·International Journal of Cancer. Journal International Du Cancer·G FritzB Kaina
Oct 6, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D B WellingL S Chang
Dec 12, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·K NiemczykF Dubrulle
May 30, 2002·The Journal of Biological Chemistry·Sophie AllartChristian Davrinche
Sep 10, 2002·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·D Bradley WellingLong-Sheng Chang
Sep 28, 2002·The Laryngoscope·John M LasakLong-Sheng Chang
Dec 11, 2002·Neurology·M E BaserD G R Evans
Mar 6, 2003·Human Mutation·Jean BénardJean-Charles Ahomadegbe
Mar 15, 2003·Nature Reviews. Cancer·Erik Sahai, Christopher J Marshall
May 23, 2003·Human Molecular Genetics·Katherine KaempchenC Oliver Hanemann
Feb 18, 2004·Archives of Otolaryngology--head & Neck Surgery·Mirko TosJens Thomsen
May 7, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·M DiensthuberT Stöver
Jun 11, 2004·American Journal of Human Genetics·Michael E BaserD Gareth R Evans
Sep 9, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Brian F O'ReillyColin Smith
Feb 9, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·D Gareth R EvansRichard Ramsden
Feb 9, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Per Cayé-ThomasenJens Thomsen
Sep 2, 2005·Nature Reviews. Genetics·Keith D Robertson
Jan 27, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Brian A NeffLong-Sheng Chang
Mar 17, 2006·The Laryngoscope·Brian A NeffLong-Sheng Chang

❮ Previous
Next ❯

Citations

May 15, 2013·Pathology Oncology Research : POR·Nives Pećina-Šlaus
Apr 21, 2016·PloS One·Hans-Juergen SchultenMohammed Al-Qahtani
Mar 10, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Christine T DinhXue-Zhong Liu
Feb 6, 2020·Acta neurochirurgica·Hjalte C R SassPer Cayé-Thomasen
Oct 18, 2019·Frontiers in Neurology·Luis LassalettaVictor Martinez-Glez

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
xenografts

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Miguel Torres-MartínJuan A Rey
Otolaryngologic Clinics of North America
Anna R Terry, Scott R Plotkin
© 2021 Meta ULC. All rights reserved