The molecular chaperone Hsp90 delivers precursor proteins to the chloroplast import receptor Toc64.

The EMBO Journal
Soumya QbadouEnrico Schleiff

Abstract

Precursor protein targeting toward organellar surfaces is assisted by different cytosolic chaperones. We demonstrate that the chloroplast protein translocon subunit Toc64 is the docking site for Hsp90 affiliated preproteins. Thereby, Hsp90 is recognised by the clamp type TPR domain of Toc64. The subsequent transfer of the preprotein from Toc64 to the major receptor of the Toc complex, namely Toc34, is affinity driven and nucleotide dependent. We propose that Toc64 acts as an initial docking site for Hsp90 associated precursor proteins. We outline a mechanism in which chaperones are recruited for a specific targeting event by a membrane-inserted receptor.

References

Mar 1, 1990·Journal of Molecular Graphics·G Vriend
Mar 22, 2000·The Journal of Cell Biology·K Sohrt, J Soll
Apr 29, 2000·Cell·B BukauE A Craig
Apr 27, 2001·Nature Structural Biology·D BrehmerB Bukau
Oct 10, 2002·FEBS Letters·Henrik Aronsson, Paul Jarvis
Feb 20, 2003·The Journal of Cell Biology·Enrico SchleiffRoswitha Harrer
Apr 1, 2003·Proceedings of the National Academy of Sciences of the United States of America·Enrico SchleiffJürgen Soll
Feb 7, 2004·The EMBO Journal·Thomas BeckerEnrico Schleiff
Mar 3, 2004·Nature Reviews. Molecular Cell Biology·Jürgen Soll, Enrico Schleiff
Jul 3, 2004·Nature Reviews. Molecular Cell Biology·Peter RehlingNikolaus Pfanner
Jul 13, 2004·Trends in Cell Biology·Felix Kessler, Danny J Schnell
Aug 20, 2004·Molecular Biology of the Cell·Thomas BeckerEnrico Schleiff
Oct 2, 2004·Nature Reviews. Molecular Cell Biology·Jason C YoungF Ulrich Hartl
Dec 4, 2004·The EMBO Journal·Jing YangDavid Barford
Dec 29, 2004·Current Biology : CB·Paul Jarvis, Colin Robinson
Aug 24, 2005·The Plant Journal : for Cell and Molecular Biology·Nancy Rosenbaum Hofmann, Steven M Theg

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Citations

Dec 9, 2010·Nature Reviews. Molecular Cell Biology·Enrico Schleiff, Thomas Becker
Feb 6, 2007·Nature Structural & Molecular Biology·Klaus RichterBrian C Freeman
Jan 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lan-Xin Shi, Steven M Theg
Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hitoshi InoueDanny J Schnell
Mar 22, 2007·BMC Evolutionary Biology·Mónica BalseraBettina Bölter
Jul 28, 2007·Biological Chemistry·Anna StengelBettina Bölter
Apr 2, 2009·Biological Chemistry·Maik S Sommer, Enrico Schleiff
Jan 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Katrin PhilipparJürgen Soll
Apr 5, 2011·Protoplasma·Verena KriechbaumerBen M Abell
Mar 3, 2010·Annual Review of Plant Biology·Hsou-min Li, Chi-Chou Chiu
Oct 16, 2014·Genome Biology and Evolution·Rajaneesh Karimpurath GopinathJun-Yi Leu
Oct 18, 2014·Journal of Experimental Botany·Monika W MurchaJames Whelan
Jan 27, 2015·Molecular Plant·Bodo TillmannEnrico Schleiff
Jun 29, 2013·Biomedical Journal·Jing Li, Johannes Buchner
Aug 13, 2010·European Journal of Cell Biology·Thomas LehmannStephan Pollmann
May 5, 2009·Current Opinion in Cell Biology·Felix Kessler, Danny Schnell
Dec 17, 2015·Planta·Tihana BiondaEnrico Schleiff
Dec 2, 2008·Trends in Plant Science·Jeferson Gross, Debashish Bhattacharya
Dec 11, 2007·Trends in Cell Biology·Mislav OrebEnrico Schleiff
Feb 20, 2007·Journal of Molecular Biology·Soumya QbadouEnrico Schleiff
Oct 23, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Andrzej BodyłJohn W Stiller
Dec 17, 2008·The New Phytologist·Paul Jarvis
Aug 30, 2007·The FEBS Journal·Lea VojtaBettina Bölter
Feb 4, 2009·The FEBS Journal·Birgit Agne, Felix Kessler
Jul 28, 2007·The Plant Journal : for Cell and Molecular Biology·Henrik AronssonPaul Jarvis
Oct 22, 2009·Traffic·Verena KriechbaumerBen M Abell
Sep 30, 2006·Current Opinion in Plant Biology·A Harvey MillarIan Small
May 27, 2011·The Biochemical Journal·Ottilie von LoeffelholzBen M Abell
Apr 24, 2012·Biochimica Et Biophysica Acta·Úrsula Flores-Pérez, Paul Jarvis
Mar 28, 2012·Biochimica Et Biophysica Acta·Dong Wook LeeInhwan Hwang
Jul 6, 2010·Biochimica Et Biophysica Acta·Markus T Bohnsack, Enrico Schleiff
Jan 27, 2010·Biochimica Et Biophysica Acta·Erika Kovács-BogdánBettina Bölter
Oct 20, 2011·Biochimica Et Biophysica Acta·Jill L Johnson

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