The molecular characteristics of bladder cancer in young patients

The Journal of Urology
J F LinnMark P Schoenberg

Abstract

The molecular characteristics of bladder cancer in children and young adults remain largely undefined. We sought to identify common molecular changes in bladder tumors in young patients using standard immunohistochemical and interphase cytogenetic methods. We retrospectively evaluated 73 bladder tumors removed from patients younger than 30 years for the p53 tumor suppressor gene product using immunohistochemical techniques and numerical aberrations of chromosomes 9, 17, X and Y. Regardless of stage, immunohistochemical evidence of p53 gene product over expression was found in the majority of tumors studied. Numerical aberrations (monosomy) of chromosome 9 were rare. Aneuploidy of chromosome 17 was common, particularly in carcinoma in situ and invasive bladder cancer. These data suggest that immunohistochemical evidence of p53 gene product over expression is common in bladder cancer in young patients. Further prospective analysis of lesions in this population may help to establish a comprehensive molecular progression model for urothelial neoplasms.

References

Apr 1, 1992·The Journal of Pathology·D Wynford-Thomas
Jan 1, 1989·Urologia Internationalis·J A Witjes, F M Debruyne
Feb 1, 1988·The Journal of Urology·H RübbenG Giani
May 1, 1969·The Journal of Urology·N Javadpour, F K Mostofi
Jul 1, 1983·The Journal of Urology·R C BensonP P Kelalis
Jul 15, 1995·Cancer Genetics and Cytogenetics·G SauterF M Waldman
Oct 1, 1994·British Journal of Urology·J A ThomasP N Matthews
Nov 10, 1994·The New England Journal of Medicine·D EsrigR J Cote
Jul 1, 1996·The Journal of Urology·D M HoenigA A Caldamone

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Citations

Apr 19, 2011·World Journal of Urology·Thomas F ChromeckiShahrokh F Shariat
Apr 15, 2004·Urologic Oncology·Ralph Madeb, Edward M Messing
Aug 13, 2009·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Parag GuptaAnil Mandhani
Aug 3, 2010·Asian Journal of Andrology·Moon Soo Ha, In Ho Chang
Apr 20, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sean R WilliamsonLiang Cheng
Sep 17, 2014·The Kaohsiung Journal of Medical Sciences·Onur TelliMuzaffer Eroglu
Oct 25, 2011·Mechanisms of Ageing and Development·Rama Devi MittalRuchika Gangwar
Nov 3, 2009·Urologic Oncology·Shahrokh F ShariatMichael J Droller
Apr 15, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Nizamettin KilicBetul Sevinir
Aug 5, 2004·BJU International·Mario MigaldiAlessandro Sgambato
Apr 28, 2011·Cancer·Kazuyoshi ShigeharaMikio Namiki
Nov 17, 2009·BJU International·Shahrokh F ShariatBernard H Bochner
Dec 14, 2011·Advances in Urology·Michael NomikosPloutarchos Anezinis
Jun 7, 2002·The Journal of Urology·Ofer Yossepowitch, Guido Dalbagni
Nov 3, 2015·Journal of Pediatric Urology·Mireia Castillo-MartinCarlos Cordon-Cardo
Aug 19, 2011·Urologia Internationalis·Nandakishore ShapurOfer N Gofrit
Jul 22, 2004·Pediatric Blood & Cancer·Pablo Lezama-del ValleThomas E Merchant
Oct 31, 2006·The Journal of Pathology·P J WildA Hartmann
Jun 28, 2008·Journal of Korean Medical Science·Sung Joon HongUNKNOWN Korean Urological Oncology Society
Dec 21, 2004·Expert Review of Anticancer Therapy·Umberto BassoSilvio Monfardini
Sep 24, 2010·Cancer Control : Journal of the Moffitt Cancer Center·Wade J SextonLoveleen C Kang
Nov 26, 2011·Expert Review of Anticancer Therapy·Armin Pycha, Evi Comploj
Mar 19, 2020·Medical Sciences : Open Access Journal·Kalyan SaginalaAlexander Barsouk

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