PMID: 9545466Jun 6, 1998Paper

The molecular clock runs at different rates among closely related members of a gene family

Journal of Molecular Evolution
P E GibbsA Dugaiczyk

Abstract

The serum albumin gene family is composed of four members that have arisen by a series of duplications from a common ancestor. From sequence differences between members of the gene family, we infer that a gene duplication some 580 Myr ago gave rise to the vitamin D-binding protein (DBP) gene and a second lineage, which reduplicated about 295 Myr ago to give the albumin (ALB) gene and a common precursor to alpha-fetoprotein (AFP) and alpha-albumin (ALF). This precursor itself duplicated about 250 Myr ago, giving rise to the youngest family members, AFP and ALF. It should be possible to correlate these dates with the phylogenetic distribution of members of the gene family among different species. All four genes are found in mammals, but AFP and ALF are not found in amphibia, which diverged from reptiles about 360 Myr ago, before the divergence of the AFP-ALF progenitor from albumin. Although individual family members display an approximate clock-like evolution, there are significant deviations-the rates of divergence for AFP differ by a factor of 7, the rates for ALB differ by a factor of 2.1. Since the progenitor of this gene family itself arose by triplication of a smaller gene, the rates of evolution of individual domains were...Continue Reading

Citations

Mar 10, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·F J Ayala
Nov 24, 1998·Trends in Genetics : TIG·L D Hurst, H Ellegren
Jul 4, 2001·Clinical Microbiology Reviews·A van BelkumM Tibayrenc
May 23, 2008·The Journal of Endocrinology·Rene F ChunMartin Hewison
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·F Rodríguez-TrellesF J Ayala
Oct 29, 2014·Genome Biology and Evolution·Alessandra MozziManuela Sironi
Mar 6, 2004·Journal of Evolutionary Biology·L E Sáenz-de-Miera, F J Ayala
Jul 6, 2000·Molecular Phylogenetics and Evolution·F Friedberg, A R Rhoads
Jan 16, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Adam ChernickFrank van der Meer
Jul 20, 2012·Journal of Bioinformatics and Computational Biology·Alexander A TerentievKonstantin V Shaitan
Jun 14, 2000·Journal of Molecular Biology·H K HamdiA Dugaiczyk
Dec 1, 1999·The Journal of Experimental Zoology·T H Waterman
Dec 5, 2002·Biochemistry·Andreas F VoegeleHans Dieplinger

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