The Molecular-Container Calabadion-2 Prevents Methamphetamine-Induced Reinstatement in Rats: A Potential Approach to Relapse Prevention?

The International Journal of Neuropsychopharmacology
Michael Z LeonardKlaus A Miczek

Abstract

Reexposure to methamphetamine with a single "priming dose" can trigger intense cravings and precipitate relapse in methamphetamine-dependent individuals. The acyclic cucurbit[n]uril "molecular container" calabadion-2 shows a high affinity to bind and sequester methamphetamine in vitro and attenuates its locomotor-stimulating effect in rats. The present study investigates whether pretreatment with calabadion-2 is sufficient to prevent the reinstatement of drug seeking by a priming dose of methamphetamine in rats. Male Long-Evans rats were trained to self-administer i.v. methamphetamine (0.06 mg/kg/infusion). Following 10 days of stable self-administration, rats underwent extinction training and were subsequently tested on a multi-phase reinstatement procedure. Drug-primed reinstatement sessions (0.3 mg/kg methamphetamine, i.v.) were preceded by either saline or calabadion-2 (130 mg/kg). Additional reinstatement tests were conducted after administration of yohimbine (1.0 mg/kg, i.v.) to define the pharmacological specificity of calabadion-2. Pretreatment with calabadion-2 significantly attenuated methamphetamine-induced reinstatement of responding. Cal2 did not affect drug-seeking behavior stimulated by the pharmacological stress...Continue Reading

References

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Jun 7, 2017·Chembiochem : a European Journal of Chemical Biology·Shweta GanapatiLyle Isaacs
Jul 21, 2017·Psychopharmacology·Michael Z LeonardKlaus A Miczek

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Citations

Oct 13, 2020·Chemical Society Reviews·Chun-Lin DengLyle D Isaacs
Jul 27, 2021·Supramolecular Chemistry·Ming Cheng, Lyle Isaacs

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BETA
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