The molecular control of meiotic chromosomal behavior: events in early meiotic prophase in Drosophila oocytes

Annual Review of Physiology
Cathleen M Lake, R Scott Hawley

Abstract

We review the critical events in early meiotic prophase in Drosophila melanogaster oocytes. We focus on four aspects of this process: the formation of the synaptonemal complex (SC) and its role in maintaining homologous chromosome pairings, the critical roles of the meiosis-specific process of centromere clustering in the formation of a full-length SC, the mechanisms by which preprogrammed double-strand breaks initiate meiotic recombination, and the checkpoints that govern the progression and coordination of these processes. Central to this discussion are the roles that somatic pairing events play in establishing the necessary conditions for proper SC formation, the roles of centromere pairing in synapsis initiation, and the mechanisms by which oocytes detect failures in SC formation and/or recombination. Finally, we correlate what is known in Drosophila oocytes with our understanding of these processes in other systems.

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Citations

Dec 25, 2013·PLoS Genetics·Nicolas ChristophorouJean-René Huynh
Nov 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yingdee Unhavaithaya, Terry L Orr-Weaver
Oct 9, 2014·Nature Communications·Gabriela CabralPeter Schlögelhofer
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Youheng WeiMary A Lilly
Mar 2, 2016·Seminars in Cell & Developmental Biology·Denise Zickler, Nancy Kleckner
Nov 26, 2015·The Journal of Cell Biology·Wing-Kit LeungHideo Tsubouchi
Oct 13, 2015·Nature Cell Biology·Nicolas ChristophorouJean-René Huynh
May 29, 2013·Molecular Reproduction and Development·Sneha Ramesh Mani, Celina E Juliano
Mar 25, 2014·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Johanna FrauneRicardo Benavente
Nov 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Liangran ZhangNancy E Kleckner
May 7, 2016·BMC Evolutionary Biology·Lucas W Hemmer, Justin P Blumenstiel
Jun 14, 2016·Current Biology : CB·Mercedes R GyuriczaKim S McKim
Sep 16, 2016·Current Genetics·Eugene Gladyshev, Nancy Kleckner
Sep 8, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jianhui JiZhukuan Cheng
Apr 23, 2016·Journal of Cell Science·Abrahan Hernández-HernándezChrister Höög
May 5, 2016·Nature Structural & Molecular Biology·Cori K Cahoon, R Scott Hawley
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Apr 28, 2019·Genetics·Michaelyn HartmannTalia Hatkevich
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Aug 2, 2017·Proceedings of the National Academy of Sciences of the United States of America·Cori K CahoonR Scott Hawley
May 13, 2020·Cells·Catherine JessusEvelyn Houliston
May 16, 2020·BMC Evolutionary Biology·Irene da CruzRicardo Benavente
Sep 21, 2016·Annual Review of Genetics·Stephen Gray, Paula E Cohen
Jan 1, 2021·The Journal of Cell Biology·Pedro BarbosaHiroyuki Ohkura
Sep 6, 2014·Journal of Cell Science·Régis E MeyerOunissa Aït-Ahmed
May 20, 2021·Open Biology·Eelco C TromerBungo Akiyoshi

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Methods Mentioned

BETA
electron microscopy
confocal microscopy
two-hybrid
chromosomal aberrations

Software Mentioned

softWoRx

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