Jun 30, 2006

The molecular diversity of glycosaminoglycans shapes animal development

Annual Review of Cell and Developmental Biology
Hannes E Bülow, Oliver Hobert

Abstract

Proteoglycans (PGs), molecules in which glycosaminoglycans (GAGs) are covalently linked to a protein core, are components of the extracellular matrix of all multicellular organisms. Sugar moieties in GAGs are often extensively modified, which make these molecules enormously complex. We discuss here the role of PGs during animal development, emphasizing the in vivo significance of sugar modifications. We explore a model in which the modification patterns of GAG chains may provide a specific code that contributes to the correct development of a multicellular organism.

  • References143
  • Citations153

Citations

Mentioned in this Paper

Vertebrates
SLC25A12 gene
Calcinus elegans
Fertility
Embryo
Cyartonema elegans
Sulfotransferase Activity
Mouse Vulva
Glypican
Coleonyx elegans

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