The molecular epidemiology of HIV-1 envelope diversity during HIV-1 subtype C vertical transmission in Malawian mother-infant pairs.

AIDS
Jesse J KwiekRonald Swanstrom

Abstract

To study the relationship between HIV-1 subtype C genetic diversity and mother-to-child transmission and to determine if transmission of HIV-1 V1/V2 env variants occurs stochastically. Case-case-control study of Malawian mother-infant pairs consisting of 32 nontransmitting women, 25 intrauterine transmitters, and 23 intrapartum transmitters in Blantyre, Malawi. A heteroduplex tracking assay against the highly variable HIV-1 env V1/V2 region was used to characterize the relationship between HIV-1 diversity and mother-to-child transmission. The relative abundance of the maternal env variants was quantified and categorized as transmitted or nontransmitted based on the env variants detected in the infant plasma. The V1/V2 region was sequenced from two mother-infant pairs and a phylogenetic tree was built. No relationship was found between transmission and overall maternal env diversity. Infants had less diverse HIV-1 populations than their mothers, and intrauterine-infected infants had fewer V1/V2 variants and were more likely to harbor a homogeneous V1/V2 population than infants infected intrapartum. V1/V2 sequences cloned from two mother-infant transmission pairs support multiple env variant transmission when multiple variants ar...Continue Reading

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Citations

Nov 3, 2010·AIDS Research and Human Retroviruses·Athena P KourtisDenise J Jamieson
Dec 31, 2011·The Journal of Infectious Diseases·Nora E RosenbergWilliam C Miller
Feb 10, 2011·Journal of Translational Medicine·Mariangela Cavarelli, Gabriella Scarlatti
Jul 6, 2013·AIDS Research and Human Retroviruses·Jessica M MatesJesse J Kwiek
Nov 17, 2010·Clinics in Perinatology·Athena P Kourtis, Marc Bulterys
May 26, 2010·International Journal of STD & AIDS·M TornatoreA M B Martinez
Apr 7, 2010·Critical Reviews in Clinical Laboratory Sciences·Tommy Tsan-Yuk LamJulian W Tang
Sep 21, 2017·Frontiers in Immunology·Ayooluwa O DouglasSallie R Permar

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