The molecular era of protein S-acylation: spotlight on structure, mechanisms, and dynamics

Critical Reviews in Biochemistry and Molecular Biology
María-Eugenia Zaballa, F Gisou van der Goot

Abstract

S-Acylation (commonly referred to as S-palmitoylation) is a post-translational modification consisting in the covalent attachment of an acyl chain to a cysteine residue of the target protein. The lability of the resulting thioester bond gives S-acylation an essential characteristic: its reversibility. S-acylation dynamically regulates different aspects in the life of a protein (including stability, localization, interactome, and function) and, thus, plays critical roles in cellular physiology. For long, the reversibility of S-acylation has been neglected and thereby its potential as a regulatory mechanism for protein function undervalued. Thanks to technological advances, the field has now entered its golden era. A great diversity of interesting targets is being identified, the physio-pathological importance of the modification is starting to be revealed, structural information on the enzymes is becoming available, and the regulatory dynamics are gradually being understood. Here we will review the most recent literature in the S-acylation field, with a special focus on the molecular aspects of the modification, its regulation, and its consequences.

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Citations

Dec 7, 2019·Expert Opinion on Drug Discovery·Mohamed Rasheed Gadalla, Michael Veit
Oct 22, 2019·Journal of Separation Science·Luisa PieroniTiziana Cabras
Dec 25, 2019·The Biochemical Journal·Mohamed Rasheed GadallaMichael Veit
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Oct 11, 2020·Journal of Cell Science·Carolina LocatelliLuke H Chamberlain
Sep 12, 2020·The Journal of Biological Chemistry·Heather McClaffertyMichael J Shipston
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Jan 18, 2021·The Journal of Biological Chemistry·Heather McClaffertyMichael J Shipston
Feb 26, 2021·Cellular Microbiology·Mohamed Rasheed GadallaMichael Veit
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Sep 8, 2021·Frontiers in Cell and Developmental Biology·Enping LiuQinmiao Sun
Oct 3, 2021·Developmental Cell·Francisco S MesquitaF Gisou van der Goot

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