The Molecular Feature of HOX Gene Family in the Intramedullary Spinal Tumors

Spine
Shixin GuRong Xie

Abstract

The expression of HOXB13 and HOXA9 proteins was detected. The purpose of this study was to investigate the molecular signature of spinal ependymoma (EPN) and astrocytoma, 2 most common types of intramedullary spinal tumor. Intramedullary spinal tumor is unusual. It leads to high neurological morbidity and mortality without treatment. Till now, its molecular feature has been elucidated up to a little extent. A total of 37 cases of spinal EPN, including 12 myxopapillary EPNs (MEPNs), 18 classic EPNs, and 7 anaplastic EPNs, and another 12 cases of astrocytoma were selected for this study. Immunohistochemical analysis of a large cohort of patients providing clinical tumor samples was performed to compare the expression of HOXB13 and HOXA9 not only between spinal EPN and astrocytoma but also among all 3 World Health Organization grades of spinal EPN. The results showed that HOXB13 and HOXA9 were selectively expressed in spinal EPN instead of astrocytoma. Furthermore, we found the strongest positive response of HOXB13 in MEPN whereas that of HOXA9 was ubiquitously detected in all subgroups of EPN. Both specificity and sensitivity of HOXB13 in MEPN indicated that HOXB13 might be a diagnostic marker to distinguish MEPN from other 2 typ...Continue Reading

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Citations

Nov 1, 2015·Clinical Neurology and Neurosurgery·Ian D ConnollyMelanie Hayden Gephart
Jul 9, 2016·Journal of Neurosurgery. Spine·Bishan D RadotraDebajyoti Chatterjee
Sep 18, 2020·Journal of Neuropathology and Experimental Neurology·Haiyin ZhengQi Zhang

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