The molecular genetic architecture of human personality: beyond self-report questionnaires

Molecular Psychiatry
R P Ebstein

Abstract

Molecular genetic studies of personality began with two high impact papers in 1996 that showed provisional associations between the dopamine DRD4 exon III repeat region and Novelty Seeking/Extraversion. These first two reports were shortly followed by an investigation linking Neuroticism/Harm Avoidance with the serotonin transporter (SLC6A4) promoter region polymorphism (5-HTTLPR). In the ensuing decade, thousands of subjects have been studied for association between these genes and personality, assessed by using self-report questionnaires, with erratic success in replication of the first findings for Novelty Seeking (DRD4) and Harm Avoidance (5-HTTLPR). Small effect sizes characteristic of non-Mendelian traits, polygenic patterns of inheritance and true heterogeneity between studies confound attempts to reach a consensus regarding the role of common polymorphisms in contributing to personality domains. Nevertheless, the current state of personality genetics is far from being bleak. Several new paradigms especially functional neuroimaging or 'imaging genomics' have strengthened the connection between 5-HTTLPR and anxiety-related personality traits. The demonstrations that early environmental information can considerably strengt...Continue Reading

References

Jul 9, 1992·Nature·H H Van TolV Jovanovic
Dec 1, 1991·Psychological Reports·C R CloningerD M Svrakic
Aug 1, 1988·The Journal of Hospital Infection·J Cohen
Aug 1, 1970·Behaviour Research and Therapy·J A Gray
Mar 1, 1995·Biological Psychiatry·N R SwerdlowD L Braff
Jan 1, 1994·Journal of Neural Transmission. General Section·K P LeschP Riederer
Dec 1, 1993·Archives of General Psychiatry·C R CloningerT R Przybeck
Jan 1, 1996·Nature Genetics·C R CloningerN M Svrakic
Nov 21, 1995·Brain Research. Developmental Brain Research·C J HeyserL H Gold
Jun 1, 1996·Journal of Neurochemistry·A HeilsK P Lesch
Jan 1, 1996·Journal of Substance Abuse·K K DowneyO F Pomerleau
Feb 1, 1997·Journal of Personality Assessment·P T Costa, R R McCrae
Jan 1, 1997·The Journal of Nervous and Mental Disease·K K DowneyB Giordani
Nov 5, 1997·Journal of Neurochemistry·C C Bradley, R D Blakely
Jun 5, 1998·American Journal of Medical Genetics·J A KnowlesT C Gilliam
Jul 23, 1998·American Journal of Medical Genetics·C R CloningerP M Conneally
Feb 10, 1999·Biological Psychiatry·T R InselJ F Leckman
Jun 12, 1999·American Journal of Human Genetics·J K Pritchard, N A Rosenberg
Aug 12, 1999·American Journal of Human Genetics·S B RobertsK S Kendler
Dec 3, 1999·American Journal of Medical Genetics·M I SeamanK K Kidd
Feb 16, 2000·Molecular Psychiatry·D Hamer, L Sirota
May 29, 2000·American Journal of Human Genetics·J K PritchardP Donnelly
Jun 3, 2000·Genetics·J K PritchardP Donnelly

❮ Previous
Next ❯

Citations

Jan 26, 2011·Der Nervenarzt·I UlrichS Barnow
Jul 6, 2007·Psychopharmacology·F Joseph McClernonRachel V Kozink
Dec 1, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Krisztina HejjasZsolt Ronai
Sep 23, 2008·European Archives of Psychiatry and Clinical Neuroscience·Xenia GondaGyorgy Bagdy
Jan 15, 2011·Bulletin of Experimental Biology and Medicine·M V AlfimovaG L Lyashenko
Feb 12, 2013·Clinical Child and Family Psychology Review·Matthew R Sanders, Trevor G Mazzucchelli
May 7, 2011·Journal of Molecular Neuroscience : MN·Ke-Sheng WangYali Liu
Aug 10, 2013·European Psychiatry : the Journal of the Association of European Psychiatrists·K LehtoJ Harro
Aug 22, 2008·Journal of Psychiatric Research·Alessandro SerrettiDan Rujescu
Oct 13, 2009·Psychiatry Research·Humberto NicoliniJames L Kennedy
Aug 9, 2007·The Pharmacogenomics Journal·A SerrettiJ L Kennedy
Jan 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Terrie E MoffittAvshalom Caspi
Oct 17, 2012·Journal of Personality Assessment·Lindsay E AyearstR Michael Bagby
Apr 21, 2011·Attachment & Human Development·Marian J Bakermans-KranenburgRobert Philibert
Mar 6, 2010·Social Cognitive and Affective Neuroscience·Julia DmitrievaYuan-Chun Ding
Jul 12, 2011·Social Cognitive and Affective Neuroscience·Alfonso TroisiCornelius Gross
May 3, 2007·Proceedings. Biological Sciences·Andrew E FidlerBart Kempenaers
Nov 17, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Daniel Nettle, Lars Penke
Nov 2, 2007·Genes, Brain, and Behavior·M H van IJzendoornJ Mesman
Dec 5, 2009·Annual Review of Psychology·Tie-Yuan Zhang, Michael J Meaney
May 18, 2011·Neuropsychobiology·Ina GieglingAlessandro Serretti
Jan 10, 2012·Neuropsychobiology·Michiko KanoShin Fukudo
Aug 25, 2010·Psychological Science·Jaime DerringerUNKNOWN Gene Environment Association Studies (GENEVA) Consortium
Dec 22, 2009·BMC Neuroscience·Ulrike M KrämerThomas F Münte
Feb 9, 2007·Annals of General Psychiatry·Alessandro SerrettiCristina Colombo
Sep 8, 2009·Child and Adolescent Psychiatry and Mental Health·Judit Gervai

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Next ❯

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