The molecular genetic basis of mitochondrial malfunction in bladder tissue following outlet obstruction

The Journal of Urology
Robert M Levin, Alan P Hudson

Abstract

Bladder dysfunction following partial outlet obstruction is a frequent consequence of benign prostatic hyperplasia and an increasingly common problem given the aging of the general population. Recent studies from this and other groups have begun to elucidate the molecular bases for the well described physiological malfunctions that characterize this clinical entity. We summarized and synthesized that information. Using modern methods of molecular genetics, including real-time polymerase chain reaction, real-time reverse transcriptase-polymerase chain reaction and others, as well as traditional experimental techniques such as electron microscopy we and others examined the transcriptional profile, morphology, etc of bladder smooth muscle mitochondria in experimental models of outlet obstruction. Data from many studies have demonstrated that aberrant gene expression in the mitochondrial and mitochondria related nuclear genetic systems underlies the loss of compliance and other attributes of bladder dysfunction following outlet obstruction. Such aberrant transcriptional characteristics engender loss of function in the electron transport and oxidative phosphorylation systems. Morphological studies of mitochondria in the animal model...Continue Reading

References

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May 1, 1990·The Journal of Urology·K KatoR M Levin
Oct 1, 1988·The Journal of Urology·K KatoR M Levin
Aug 1, 1986·British Journal of Urology·S A GilpinR S Kirby
Oct 1, 1984·The Journal of Urology·R M LevinA J Wein
Oct 1, 1981·Cell·M J BibbD A Clayton
Mar 16, 1994·Molecular and Cellular Biochemistry·M W ChenR Buttyan
Feb 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·N G LarssonD A Clayton
Jan 1, 1997·Neurourology and Urodynamics·J A HypoliteR M Levin
Jan 1, 1997·Basic Research in Cardiology·A G Kleber, V Fast
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Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·H C AuI E Scheffler

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Citations

Sep 23, 2008·The Journal of Urology·Yung-Shun JuanAnita Mannikarottu
Jan 3, 2007·Journal of the American Geriatrics Society·John A Taylor, George A Kuchel
Dec 24, 2010·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Vijay VenugopalRobert M Levin
Jul 13, 2006·American Journal of Physiology. Renal Physiology·John A TaylorGeorge A Kuchel
Sep 3, 2020·Prostate Cancer and Prostatic Diseases·Junjie ZhangLong Wang

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