The molecular genetics of human sleep.

The European Journal of Neuroscience
Luoying Zhang, Ying-Hui Fu

Abstract

It has been known for many years that genetic influences account for some of the individual differences in human sleep parameters, but the underlying molecular mechanisms remain unclear. With major advances of molecular biology and the recognition of heritable sleep behaviors in humans over the past 30 years, a number of genetic variants have been identified to be associated with human sleep timing, duration and quality, both in healthy individuals and under pathological conditions. Some of these variants were further validated and characterized in animal models, shedding light on the mechanism of how these variants likely alter sleep in humans, which may provide new insights into developing more effective treatments to improve human sleep.

References

Feb 13, 1992·The New England Journal of Medicine·R MedoriP Cortelli
May 23, 1997·Science·T Porkka-HeiskanenR W McCarley
Mar 2, 2005·Sleep Medicine Reviews·Y DauvilliersMehdi Tafti
Jun 21, 2005·Nature Neuroscience·Zhi-Li HuangOsamu Hayaishi
Oct 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·J V RéteyH-P Landolt
Mar 10, 2007·Current Biology : CB·Antoine U ViolaDerk-Jan Dijk
Jul 20, 2007·The New England Journal of Medicine·Hreinn StefanssonKari Stefansson
Dec 7, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Juliane WinkelmannBertram Müller-Myhsok
Jul 21, 2009·Nature Reviews. Neuroscience·Chiara Cirelli
Jul 8, 2011·Cerebral Cortex·Valérie BachmannHans-Peter Landolt
Jul 26, 2011·Cell·Amita Sehgal, Emmanuel Mignot
Jun 5, 2012·Current Biology : CB·Amanda FreemanSubhabrata Sanyal
Nov 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Stephen R MorairtyThomas S Kilduff
Mar 1, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sibah HasanSimon N Archer
Oct 11, 2014·Journal of Neural Transmission·Félix Javier Jiménez-JiménezJosé A G Agúndez
Jun 16, 2015·American Journal of Respiratory and Critical Care Medicine·Sutapa MukherjeeUNKNOWN American Thoracic Society ad hoc Committee on Healthy Sleep
Oct 16, 2015·Human Molecular Genetics·Brian E CadeRicha Saxena
Jan 15, 2016·Journal of Sleep Research·Alexander A BorbélyTom Deboer
Feb 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Luoying ZhangYing-Hui Fu
Aug 17, 2016·ELife·Arisa HiranoYing-Hui Fu
Jan 20, 2017·Lancet Neurology·Olivia J VeatchAllan I Pack
Apr 25, 2017·Science Advances·Jason R GerstnerMarcos G Frank
Jul 6, 2017·Scientific Reports·Karla V AllebrandtCristiano De Pittà
Oct 13, 2017·Current Opinion in Neurobiology·Mauro DiNuzzo, Maiken Nedergaard
Mar 14, 2018·Proceedings of the National Academy of Sciences of the United States of America·Arisa HiranoYing-Hui Fu

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