The Molecular Genetics of Restless Legs Syndrome

Sleep Medicine Clinics
David B Rye

Abstract

Restless legs syndrome (RLS) is a common sensorimotor trait defined by symptoms that interfere with sleep onset and maintenance in a clinically meaningful way. Nonvolitional myoclonus while awake and asleep is a sign of the disorder and an informative endophenotype. The genetic contributions to RLS/periodic leg movements are substantial, are among the most robust defined to date for a common disease, and account for much of the variance in disease expressivity. The disorder is polygenic, as revealed by recent genome-wide association studies. Experimental studies are revealing mechanistic details of how these common variants might influence RLS expressivity.

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Aug 5, 2017·Continuum : Lifelong Learning in Neurology·Lynn Marie Trotti
Aug 5, 2017·Continuum : Lifelong Learning in Neurology·Suresh Kotagal
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Sep 19, 2021·Sleep·Raffaele FerriLourdes M Del Rosso

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