The molecular genetics of type-4 fimbriae in Pseudomonas aeruginosa--a review

Gene
J S MattickR A Alm

Abstract

Type-4 fimbriae (or pili) are filaments found at the poles of a wide range of bacterial pathogens, including Neisseria gonorrhoeae, Moraxella bovis, Dichelobacter nodosus and Pseudomonas aeruginosa. They are composed of a small subunit which is highly conserved among different species and appear to mediate adhesion and translocation across epithelial surfaces via a phenomenon termed "twitching motility'. These fimbriae are key host colonisation factors and important protective antigens. We have analysed the genetics and biosynthesis of type-4 fimbriae in P. aeruginosa, which is an opportunistic pathogen of compromised individuals, including those suffering cystic fibrosis, AIDS or burns. A library of P. aeruginosa transposon mutants was constructed which exhibited loss of twitching motility, as determined by altered colony morphology. Analysis of these mutants, and of similar collections by other groups, have revealed that there are at least 22 genes involved in type-4 fimbrial assembly and function. A large number (pilA, B, C, D, E, M, N, O, P, Q, T, U, V and Z) appear to be involved in the biogenesis of the fimbriae and to represent a subset of a supersystem involved in the assembly of surface-associated protein complexes. Ho...Continue Reading

References

Jan 1, 1975·Annual Review of Microbiology·J C Ottow
Nov 1, 1992·Journal of Bacteriology·P A HoyneT C Elleman
Sep 1, 1992·FEMS Microbiology Reviews·J TommassenA Lazdunski
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D N Nunn, S Lory
May 1, 1990·Journal of Bacteriology·M K BeardJ R Egerton
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S Y HeA Collmer
Jan 1, 1990·Annual Review of Genetics·A P PugsleyM G Kornacker
Mar 1, 1989·Molecular & General Genetics : MGG·P A CastricJ C Sadoff
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K S Ishimoto, S Lory
Aug 1, 1988·Journal of Bacteriology·B L PasloskeW Paranchych
Jan 1, 1987·Journal of Bacteriology·J S MattickJ R Egerton
Jan 1, 1988·Advances in Microbial Physiology·W Paranchych, L S Frost
Apr 22, 1985·FEBS Letters·B L PasloskeW Paranchych
Jan 1, 1987·Journal of Molecular Evolution·B Dalrymple, J S Mattick
Sep 1, 1972·Journal of General Microbiology·D E Bradley
Feb 1, 1980·Canadian Journal of Microbiology·D E Bradley
Jan 1, 1983·Annual Review of Microbiology·J Henrichsen
Jan 1, 1993·Annual Review of Microbiology·M S Strom, S Lory

❮ Previous
Next ❯

Citations

Oct 15, 2003·Journal of Molecular Biology·Mark A RobienWim G J Hol
Jul 24, 2003·Trends in Microbiology·Nicholas P WestChristoph M Tang
Apr 1, 2000·Microbes and Infection·M S Strom, R N Paranjpye
May 3, 2002·Molecular Microbiology·Geneviève BallAlain Filloux
Jun 2, 2009·Médecine sciences : M/S·Nicolas Biais
Dec 16, 2011·Molecular Plant-microbe Interactions : MPMI·Charles K WairuriJacques Theron
Jan 17, 2012·Applied and Environmental Microbiology·David LalaounaWafa Achouak
Oct 16, 2002·Infection and Immunity·Stephen E LizewskiMichael J Schurr
Apr 23, 2004·Infection and Immunity·Horacio GilDavid G Thanassi
Dec 19, 2006·Journal of Bacteriology·Kenlee NakasugiBrett A Neilan
Apr 10, 2007·Journal of Bacteriology·Paula S DugganDavid G Adams
Aug 19, 2003·Journal of Bacteriology·Vesna SimunovicLawrence J Shimkets
Mar 20, 2003·Journal of Bacteriology·Karin HeurlierDieter Haas
Oct 14, 2000·Annual Review of Cell and Developmental Biology·A J Merz, M So
Jun 2, 2004·Journal of Molecular Microbiology and Biotechnology·Eric Nudleman, Dale Kaiser
Jan 26, 2011·PloS One·Yuki F InclanJoanne N Engel
Oct 31, 2002·Molecular Microbiology·Antonio DiGiandomenicoPeter Castric
Aug 21, 2010·Future Microbiology·Melissa AyersLori L Burrows
Jun 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·J M Skerker, H C Berg
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·I ValletA Filloux
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·D BhayaA R Grossman
Apr 27, 1999·Molecular Microbiology·D Wall, D Kaiser
Jul 4, 2012·Annual Review of Microbiology·Lori L Burrows
Feb 24, 2001·Molecular Plant-microbe Interactions : MPMI·Y ShenP Ronald
Feb 7, 2001·Trends in Microbiology·J B Goldberg
Mar 18, 2009·Cellular and Molecular Life Sciences : CMLS·Anne BernaAndrew Suh
May 25, 2011·Microbial Pathogenesis·Nicole M Ark, Barbara J Mann
Feb 5, 2008·Journal of Molecular Biology·Marissa E YanezWim G J Hol

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.