The Molecular Intersection Between Senescence and Major Depression in the Elderly

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Breno Satler Diniz

Abstract

Major depressive disorder in the elderly-or late-life depression (LLD)-is one of the most common mental illnesses in the aging population. LLD has several negative effects on health and well-being. Individuals with LLD have an elevated risk of chronic and persistent depressive symptoms as well as high rates of treatment resistance. They also have a higher risk of developing cognitive impairment with progression to dementia and higher rates of medical comorbidity, frailty, and mortality. The mechanisms linking LLD to these adverse health outcomes are not well understood. In this article, we review the evidence that individuals with LLD present with, i.e., enhanced molecular and cellular senescent changes, focusing on the senescence-associated secretory phenotype (SASP). We then propose a mechanistic model linking SASP to the greater risk of negative health outcomes in this population. We finally provide evidence that SASP-and cellular senescence in general-can be a therapeutic target for mitigating the risk of these negative outcomes in LLD.

Citations

Aug 7, 2019·Journal of Cellular Biochemistry·Jiezhong Chen, Luis Vitetta
May 23, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Astrid LugtenburgRichard C Oude Voshaar
Aug 23, 2019·Translational Psychiatry·Breno S DinizBrenda W J H Penninx
Apr 2, 2020·Frontiers in Pharmacology·Christoph Linnemann, Undine E Lang
Oct 13, 2020·Journal of Affective Disorders·Erica L VieiraBreno S Diniz
Apr 6, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Breno S DinizUNKNOWN on behalf of the PACt‐MD Study Group
May 23, 2021·Journal of Psychiatric Research·Vanessa F GonçalvesBreno Diniz
Jun 16, 2021·International Journal of Geriatric Psychiatry·Richard C Oude VoshaarHans W Jeuring
Jun 22, 2021·Brain and Behavior·Ana Paula Mendes-SilvaBreno Satler Diniz

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