The molecular language of membraneless organelles

The Journal of Biological Chemistry
Edward Gomes, James Shorter


Eukaryotic cells organize their intracellular components into organelles that can be membrane-bound or membraneless. A large number of membraneless organelles, including nucleoli, Cajal bodies, P-bodies, and stress granules, exist as liquid droplets within the cell and arise from the condensation of cellular material in a process termed liquid-liquid phase separation (LLPS). Beyond a mere organizational tool, concentrating cellular components into membraneless organelles tunes biochemical reactions and improves cellular fitness during stress. In this review, we provide an overview of the molecular underpinnings of the formation and regulation of these membraneless organelles. This molecular understanding explains emergent properties of these membraneless organelles and shines new light on neurodegenerative diseases, which may originate from disturbances in LLPS and membraneless organelles.


Jun 1, 1979·Cell·M Ashburner, J J Bonner
Sep 1, 1981·Developmental Biology·J J Bonner
Jul 17, 2004·The EMBO Journal·Nina SchaffertReinhard Lührmann
Sep 17, 2004·Molecular Biology of the Cell·Natalie GilksPaul Anderson
Jun 3, 2005·Nature Reviews. Genetics·James Shorter, Susan Lindquist
Dec 6, 2005·Trends in Cell Biology·Korie E Handwerger, Joseph G Gall
Jul 11, 2006·Nature Reviews. Molecular Cell Biology·Valérie SchreiberGilbert de Murcia
Nov 4, 2006·Molecular Cell·Tian Huai ShenPier Paolo Pandolfi
Nov 4, 2009·Molecular and Cellular Biology·James A ToombsEric D Ross
Feb 5, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Shilpa VashistJames Shorter
Apr 2, 2010·Journal of Cell Science·Mimi CushmanJames Shorter
Dec 21, 2010·Nature Cell Biology·Yuntao S MaoDavid L Spector
Dec 24, 2010·Molecular Biology of the Cell·Ivan NovotnýJan Malinsky
Jan 18, 2011·Nature Cell Biology·Sergey P Shevtsov, Miroslav Dundr
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Clifford P BrangwynneAnthony A Hyman
May 21, 2011·Molecular Cell·Anthony K L LeungPaul Chang
Jun 18, 2011·Trends in Genetics : TIG·Yuntao S MaoDavid L Spector
Jul 20, 2011·Cold Spring Harbor Perspectives in Biology·Ekaterina VoroninaIppei Nagamori
Nov 3, 2011·Cold Spring Harbor Perspectives in Biology·Morgan Sheng, Eunjoon Kim
Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Julien CouthouisAaron D Gitler
Mar 29, 2012·Human Molecular Genetics·Julien CouthouisAaron D Gitler
Apr 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·James A ToombsEric D Ross
Jul 6, 2012·Cold Spring Harbor Perspectives in Biology·Carolyn J Decker, Roy Parker
Jul 28, 2012·Biochemical and Biophysical Research Communications·Chung-ke ChangJoseph Jen-Tse Huang
Oct 24, 2012·Nature Chemistry·Christopher A StrulsonPhilip C Bevilacqua
May 1, 2013·The Journal of Cell Biology·Yun R LiAaron D Gitler
Jun 12, 2013·Molecular Cell·Palaniraja ThandapaniStéphane Richard
Dec 3, 2013·Current Biology : CB·Valeria CherkasovBernd Bukau
Dec 18, 2013·Human Molecular Genetics·Tatyana A ShelkovnikovaVladimir L Buchman
Jan 21, 2014·Cell·Meredith E JackrelJames Shorter
Jun 11, 2014·The Journal of Cell Biology·Anthony K L Leung

❮ Previous
Next ❯


Feb 23, 2019·Biomolecules·Taranpreet KaurPriya R Banerjee
May 18, 2019·The Journal of Biological Chemistry·Solomiia BoykoWitold K Surewicz
Jul 31, 2019·Protein Science : a Publication of the Protein Society·Juan C Aledo
Oct 31, 2019·Traffic·Celestin N MudogoChristian Betzel
Oct 23, 2019·The Journal of Cell Biology·Haiyan AnTatyana A Shelkovnikova
Sep 1, 2019·Cells·Chujun Zhang, Catherine Rabouille
Sep 13, 2019·Biomolecules·Boris Y ZaslavskyVladimir N Uversky
Jan 28, 2020·PLoS Computational Biology·Sean M CascarinaEric D Ross
Feb 12, 2020·Medicinal Research Reviews·Heike J WobstJames Shorter
Feb 1, 2020·Annual Review of Biophysics·Jeong-Mo ChoiRohit V Pappu
Aug 4, 2019·Journal of Virology·Yuqin ZhouDzwokai Ma
Jun 9, 2020·Small·Giuseppe ArrabitoBruno Pignataro
Jun 7, 2020·Cells·Melis Dilara ArslanhanElif Nur Firat-Karalar
May 14, 2020·Molecular Biology of the Cell·Kaitlin P KoreskiRobert J Duronio
Jul 9, 2020·Physical Chemistry Chemical Physics : PCCP·Cecília FerreiraPedro Miguel Martins
Jul 9, 2020·Emerging Topics in Life Sciences·Hana M Odeh, James Shorter
Dec 11, 2019·Biomolecules·Vladimir N Uversky, Alexei V Finkelstein
Nov 7, 2019·Nucleic Acids Research·Wanshan NingYu Xue
Aug 5, 2020·Expert Opinion on Therapeutic Targets·Yiran Wang, Rickie Patani
Sep 3, 2020·Briefings in Bioinformatics·Chunyu YuTingting Li
Sep 30, 2020·RNA Biology·Julie Qiaojin LinChristine E Holt
Nov 9, 2018·Frontiers in Synaptic Neuroscience·Lennart Brodin, Oleg Shupliakov
Oct 18, 2019·Frontiers in Pharmacology·Jack M WebsterLaura J Blair
May 13, 2020·Proceedings of the National Academy of Sciences of the United States of America·Benjamin S SchusterJeetain Mittal
Mar 21, 2019·Nature Reviews. Neurology·Natalia B Nedelsky, J Paul Taylor
Apr 30, 2020·Biomolecules·Peder A G LillebostadPetri Kursula
Jun 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ibraheem AlshareedahPriya R Banerjee
Sep 30, 2020·International Journal of Molecular Sciences·Maria V SukhanovaOlga I Lavrik
Sep 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vladimir N Uversky
Jan 4, 2019·Current Genetics·Elio A Abbondanzieri, Anne S Meyer
Aug 19, 2020·Nature Structural & Molecular Biology·Bridget E BeggChristopher B Burge
Jul 28, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Therese C KichukJosé L Avalos
Apr 20, 2019·Frontiers in Molecular Biosciences·Karina K NakashimaEvan Spruijt

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Related Papers

Biochemical Society Transactions
Aristeidis P SfakianosMark P Ashe
The EMBO Journal
Edward M CourchaineKarla M Neugebauer
© 2021 Meta ULC. All rights reserved