The molecular mechanism of SLC34 proteins: insights from two decades of transport assays and structure-function studies

Pflügers Archiv : European journal of physiology
Ian C Forster

Abstract

The expression cloning some 25 years ago of the first member of SLC34 solute carrier family, the renal sodium-coupled inorganic phosphate cotransporter (NaPi-IIa) from rat and human tissue, heralded a new era of research into renal phosphate handling by focussing on the carrier proteins that mediate phosphate transport. The cloning of NaPi-IIa was followed by that of the intestinal NaPi-IIb and renal NaPi-IIc isoforms. These three proteins constitute the main secondary-active Na+-driven pathways for apical entry of inorganic phosphate (Pi) across renal and intestinal epithelial, as well as other epithelial-like organs. The key role these proteins play in mammalian Pi homeostasis was revealed in the intervening decades by numerous in vitro and animal studies, including the development of knockout animals for each gene and the detection of naturally occurring mutations that can lead to Pi-handling dysfunction in humans. In addition to characterising their physiological regulation, research has also focused on understanding the underlying transport mechanism and identifying structure-function relationships. Over the past two decades, this research effort has used real-time electrophysiological and fluorometric assays together with...Continue Reading

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Citations

Jun 7, 2019·Nature Reviews. Nephrology·Moshe LeviHeini Murer
Mar 11, 2020·Genes·Daniela Iancu, Emma Ashton
Apr 21, 2020·The Journal of Clinical Endocrinology and Metabolism·Rebecca J GordonMichael A Levine
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Dec 21, 2018·Pflügers Archiv : European journal of physiology·Heini MurerAndreas Werner
May 1, 2020·Physiological Reviews·Nati HernandoEleanor Lederer
Dec 14, 2018·Pflügers Archiv : European journal of physiology·Tiziano Verri, Andreas Werner
Jul 26, 2019·Physiological Reports·Natsuki MizutaniYasushi Okamura
Apr 9, 2020·Calcified Tissue International·Munro Peacock
Mar 16, 2021·Frontiers in Cell and Developmental Biology·Amy B P RibetNathan J Pavlos
Aug 29, 2020·Bone·Paul H SchlesingerHarry C Blair

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