The molecular mechanisms mediating mammalian fertilization

Development
Hanisha H BhaktaMatteo A Avella

Abstract

Fertilization is a key biological process in which the egg and sperm must recognize one another and fuse to form a zygote. Although the process is a continuum, mammalian fertilization has been studied as a sequence of steps: sperm bind and penetrate through the zona pellucida of the egg, adhere to the egg plasma membrane and finally fuse with the egg. Following fusion, effective blocks to polyspermy ensure monospermic fertilization. Here, we review how recent advances obtained using genetically modified mouse lines bring new insights into the molecular mechanisms regulating mammalian fertilization. We discuss models for these processes and we include studies showing that these mechanisms may be conserved across different mammalian species.

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Citations

Dec 18, 2019·Biochemical Society Transactions·Almut Dufner, Klaus-Peter Knobeloch
May 30, 2020·Development·David A Cruz Walma, Kenneth M Yamada
Apr 11, 2020·Reproductive Medicine and Biology·Ken-Ichi Sato, Alexander A Tokmakov
Oct 6, 2020·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Jolie A Carlisle, Willie J Swanson
Mar 6, 2021·Frontiers in Cell and Developmental Biology·Emma LinnMatteo Avella
May 1, 2021·Biology of Reproduction·Millissia Ben MaamarMichael K Skinner
Jul 30, 2021·Advanced Genetics·Xue Mei, Andrew W Singson
Aug 28, 2021·International Journal of Molecular Sciences·Martin AngerMarketa Charousova

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