PMID: 11915927Mar 28, 2002Paper

The molecular responses of skeletal muscle satellite cells to continuous expression of IGF-1: implications for the rescue of induced muscular atrophy in aged rats

International Journal of Sport Nutrition and Exercise Metabolism
Manu V ChakravarthyEspen E Spangenburg

Abstract

Approximately 50% of humans older than 85 years have physical frailty due to weak skeletal muscles. This indicates a need for determining mechanisms to combat this problem. A critical cellular factor for postnatal muscle growth is a population of myogenic precursor cells called satellite cells. Given the complex process of sarcopenia, it has been postulated that, at some point in this process, a limited satellite cell proliferation potential could become rate-limiting to the regrowth of old muscles. It is conceivable that if satellite cell proliferative capacity can be maintained or enhanced with advanced age, sarcopenia could potentially be delayed or prevented. Therefore, the purposes of this paper are to describe whether IGF-I can prevent muscular atrophy induced by repeated cycles of hindlimb immobilization, increase the in vitro proliferation in satellite cells from these muscles and, if so, the molecular mechanisms by which IGF-I mediates this increased proliferation. Our results provide evidence that IGF-I can enhance aged muscle regrowth possibly through increased satellite cell proliferation. The results also suggest that IGF-I enhances satellite cell proliferation by decreasing the cell cycle inhibitor, p27Kip1, throu...Continue Reading

Citations

Apr 22, 2005·Reviews in Endocrine & Metabolic Disorders·John E MorleyMatthew T Haren
Aug 19, 2010·Journal of Muscle Research and Cell Motility·Quinlyn A SoltowDavid S Criswell
Jun 15, 2011·Cell and Tissue Research·Neill J Turner, Stephen F Badylak
Dec 17, 2014·Molecular and Cellular Biochemistry·Matthias TotzeckUlrike B Hendgen-Cotta
Sep 6, 2020·International Journal of Molecular Sciences·Shingo YokoyamaKatsumasa Goto
Oct 24, 2002·Clinical Orthopaedics and Related Research·Vincent J Caiozzo, Stuart Green
Mar 8, 2012·Journal of Tissue Engineering and Regenerative Medicine·Xiaorong MaFang Chen
Mar 31, 2007·Journal of Applied Physiology·Marcas M BammanJames M Cross
May 10, 2008·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Patrick WahlWilhelm Bloch
Mar 15, 2005·BMC Musculoskeletal Disorders·Marion M SchuiererSimon M Hughes
Jul 17, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Srinivasan DasarathyArthur J McCullough
Aug 11, 2004·Experimental Cell Research·V JacqueminV Mouly
Sep 20, 2005·Experimental Cell Research·Jeffrey S OtisGrace K Pavlath

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.