The molecular ticks of the Drosophila circadian clock

Current Opinion in Insect Science
Ozgur Tataroglu, Patrick Emery


Drosophila is a powerful model to understand the mechanisms underlying circadian rhythms. TheDrosophilamolecular clock is comprised of transcriptional feedback loops. The expressions of the critical transcriptional activator CLK and its repressors PER and TIM are under tight transcriptional control. However, posttranslational modification of these proteins and regulation of their stability are critical to their function and to the generation of 24-hr period rhythms. We review here recent progress made in our understanding of PER, TIM and CLK posttranslational control. We also review recent studies that are uncovering the importance of novel regulatory mechanisms that affect mRNA stability and translation of circadian pacemaker proteins and their output.


Mar 14, 1996·Nature·H ZengMichael Rosbash
Jan 31, 1998·The EMBO Journal·W V So, Michael Rosbash
Nov 24, 2001·Neuron·A Claridge-ChangM W Young
Feb 21, 2002·The Journal of Biological Chemistry·Hiroki R UedaSeiichi Hashimoto
Nov 26, 2002·Nature·Jui-Ming LinRavi Allada
Sep 10, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yiing LinPaul H Taghert
Apr 10, 2007·Cell·Dan StoleruMichael Rosbash
Jun 21, 2007·Genes & Development·Sebastian KadenerMichael Rosbash
Jan 24, 2008·Current Biology : CB·Michael N Nitabach, Paul H Taghert
Feb 21, 2008·BMC Genomics·Maocheng YangIsaac Edery
Sep 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rose-Anne MeissnerRavi Allada
Jul 1, 2009·The Journal of Biological Chemistry·Hsiu-Cheng HungFrank Weber
Aug 22, 2009·Genes & Development·Sebastian KadenerMichael Rosbash
Feb 18, 2010·Genes & Development·Jerome S MenetMichael Rosbash
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Elzbieta Kula-EversoleMichael Rosbash
Jul 16, 2010·Trends in Neurosciences·Steven M ReppertChristine Merlin
Apr 29, 2011·EMBO Reports·Angélique LamazeFrançois Rouyer
May 10, 2011·Current Biology : CB·Laura B Duvall, Paul H Taghert
Feb 14, 2012·Genes & Development·Eun Young KimJin Won Cho
Apr 25, 2012·Annual Review of Biochemistry·David Komander, Michael Rape
May 29, 2012·Molecular Cell·Yoosik Kim, V Narry Kim
Jun 2, 2012·Journal of Biological Rhythms·Vasudha SundramF R Jackson
Aug 11, 2012·PLoS Biology·Brigitte GrimaFrançois Rouyer
Nov 17, 2012·Genes & Development·Weifei LuoMichael Rosbash
Jan 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Joseph RodriguezMichael Rosbash


Feb 10, 2016·Frontiers in Physiology·Chihiro Ito, Kenji Tomioka
Aug 4, 2016·FEBS Letters·Christian MaurerFrank Weber
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Tianxin LiuPaul E Hardin
Sep 5, 2017·Journal of Neurogenetics·Patricia Jarabo, Francisco A Martin
Oct 27, 2018·Genome Génome / Conseil National De Recherches Canada·Qian Cong, Nick V Grishin
Jan 18, 2018·BMC Neuroscience·Yongbo Xue, Yong Zhang
Nov 4, 2017·RNA Biology·Sarah Catherine MillsAlbrecht G von Arnim
Oct 1, 2018·The European Journal of Neuroscience·Aliza K De Nobrega, Lisa C Lyons
Oct 23, 2019·Annual Review of Physiology·Christi M GendronScott D Pletcher
Jul 28, 2020·Journal of Neurochemistry·Shashank Bangalore Srikanta, Nicolas Cermakian
Nov 25, 2018·International Journal of Molecular Sciences·Zhaojiang GuoYoujun Zhang
Aug 31, 2020·BMC Genomics·Mirko PegoraroEran Tauber
May 24, 2017·Annual Review of Vision Science·Russell N Van Gelder, Ethan D Buhr
May 18, 2018·Frontiers in Neural Circuits·Wojciech KrzeptowskiElżbieta Pyza
Mar 19, 2019·Frontiers in Cellular Neuroscience·Wenfeng ChenYong Zhang
Jan 24, 2020·Frontiers in Physiology·Angélique Lamaze, Ralf Stanewsky
Mar 21, 2019·Zoological Letters·Hiroyuki J KanayaTaichi Q Itoh
Apr 18, 2020·Frontiers in Physiology·Magdalena Maria KaniewskaJoanna Kotwica-Rolinska
Oct 27, 2018·Molecular Phylogenetics and Evolution·Clare H Scott ChialvoKelly A Dyer

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.