PMID: 9446856Mar 7, 1998Paper

The mongolian gerbil (Meriones unguiculatus) is an appropriate animal model for evaluation of the conversion of beta-carotene to vitamin A

The Journal of Nutrition
C M LeeJ W Erdman

Abstract

Vitamin A (VA) deficiency is the leading cause of blindness in children in developing countries. Dietary intervention with foods rich in provitamin A carotenoids, such as beta-carotene (betaC), has been suggested as one solution to this problem. The objective of the two studies described in this paper was to examine the utilization of betaC as a source of VA at different stages of VA depletion using the Mongolian gerbil as a model. Male 4- to 5-wk-old Mongolian gerbils were fed powdered betaC-free semipurified diets either with or without VA for 26 d (Study 1), or without VA for 8-10 wk (Study 2). Gerbils were then fed diets with or without VA (20.9 nmol/g diet) and/or betaC [(67.0 micromol/g diet (Study 1) and 145.9 micromol/g diet (Study 2)] for variable periods. Two (Study 1) or three (Study 2) days before termination of the study, 3-4 gerbils per group were dosed orally with 14C-betaC. Tissues were evaluated for VA and betaC content by HPLC. Liver was extracted with and without saponification to evaluate 14C-betaC and 14C-VA content. The results demonstrate the following: 1) the gerbil is an appropriate animal model to study betaC utilization; 2) 20.9 nmol VA/g diet is more than sufficient for this species; 3) the daily VA ...Continue Reading

References

Apr 1, 1989·The Journal of Nutrition·J D Ribaya-MercadoR M Russell
Dec 31, 1993·Annals of the New York Academy of Sciences·H K Biesalski, H Weiser
Jun 1, 1994·The Journal of Nutrition·J PollackJ W Erdman
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Mar 7, 1998·The Journal of Nutrition·J D LedermanJ W Erdman

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Citations

Mar 7, 1998·The Journal of Nutrition·J D LedermanJ W Erdman
Aug 22, 2008·The Journal of Nutrition·Jordan P MillsSherry A Tanumihardjo
Feb 21, 2013·Nutrition Research and Practice·Soo-Kyong Choi, Jung-Sook Seo
Oct 2, 2014·Journal of the Science of Food and Agriculture·Betty J Burri
Jun 19, 2010·Experimental Biology and Medicine·Sara A ArscottSherry A Tanumihardjo
Apr 3, 2014·Nutrition Reviews·Michael R La FranoBetty J Burri
Nov 30, 2013·Nutrients·Varsha Shete, Loredana Quadro
Nov 24, 1999·Nutrition Reviews·J W FaheyR M Russell
Sep 22, 2006·The Journal of Nutrition·Julie A Howe, Sherry A Tanumihardjo
Feb 2, 2002·The Journal of Nutrition·Ahmad SulaemanJudy A Driskell
Nov 26, 1999·The Journal of Nutrition·C M LeeJ W Erdman
Nov 12, 2016·TheScientificWorldJournal·Alice S Green, Andrea J Fascetti
Oct 1, 2008·Comprehensive Reviews in Food Science and Food Safety
Jun 14, 2005·Biochimica Et Biophysica Acta·Ralph Rühl

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