The monitoring and preventing of spinal cord ischemic injury during thoracic descending aortic operating

Scandinavian Cardiovascular Journal : SCJ
Feng LiuPeiqing Dong

Abstract

A model of ischemic injury to the spinal cord was established in pigs by clamping the thoracic descending aorta. The feasibility of monitoring spinal-cord ischemia using the cortical somatosensory evoked potential (CSEP) was evaluated. Outcomes between the simple clamp (SC) group and left-heart bypass (LHB) group were compared. Twelve mini-pigs were randomly divided into two groups SC group and LHB group randomly. The left intercostal incision was adopted. The thoracic descending aorta was clamped under the left innominate artery outlet. CSEP was recorded to monitor the function of the spinal cord. The behavior score was observed every day after surgery. Mini-pigs were killed on the seventh postoperative day. Ultrastructural changes were observed by transmission electron microscopy. The surgical procedures were successful. Two animals developed incomplete paralysis and the remainder developed paraplegia in the SC group. The animals in the LHB group recovered completely and paralysis/paraplegia was not observed. CSEP measurements showed that the amplitude decreased to <50% of baseline values and prolongation of latency was >10% of baseline values in the SC group but not in the LHB group. Changes in CSEP values were in accordance...Continue Reading

References

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Citations

Mar 4, 2014·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Ovunc AkdemirOytun Erbas

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