The monoamine oxidase inhibitory activity of essential oils obtained from Eryngium species and their chemical composition

Pharmaceutical Biology
Luiz Carlos Klein-JúniorAmélia Teresinha Henriques

Abstract

Monoamine oxidase (MAO) inhibitors are used in the treatment of depression, anxiety disorders, and the symptomatic treatment of Parkinson's disease. Eryngium, the most representative of the Apiaceae family, is well known for the presence of essential oils (EOs), which have already demonstrated MAO inhibitory potential. The objective of this study is to evaluate the MAO inhibitory capacity of the EOs obtained from Eryngium floribundum Cham. & Schlecht. (EF), E. eriophorum Cham. & Schlecht. (EE), E. nudicaule Lam. (EN), E. horridum Malme (EH), and E. pandanifolium Cham. & Schlecht. (EP). EOs were obtained from fresh whole plants by hydrodistillation (3 h). Chemical analyses were performed by GC/MS using apolar and polar columns, with oven temperature from 60 to 300 °C at 3 °C/min. The MAO-A and -B activities were evaluated in vitro by an end-point method using kynuramine as the substrate and mitochondrial suspension or human recombinant enzymes as the enzymatic source. DMSO 2%, clorgyline 10(-7) M, and pargyline 10(-6) M were used as controls. EFEO, EEEO, ENEO, EHEO, and EPEO GC/MS analysis showed (E)-caryophyllene (4.9-10.8%), germacrene D (0.6-35.1%), bicyclogermacrene (10.4-17.2), spathulenol (0.4-36.0%), and globulol (1.4-18....Continue Reading

References

Apr 24, 1980·Biochimica Et Biophysica Acta·T J McIntoshR C MacDonald
Jul 1, 1993·Journal of Pharmaceutical and Biomedical Analysis·M Szögyi, T Cserháti
Nov 7, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E M Williamson
Jun 7, 2005·Bioorganic & Medicinal Chemistry·Guoxin TaoWing Ming Keung
Jun 9, 2005·Journal of Chromatography. a·Jesús Palá-PaúlJoseph J Brophy
Aug 2, 2005·Bioorganic & Medicinal Chemistry·Laura NovaroliPierre-Alain Carrupt
Oct 6, 2005·Journal of Chromatography. a·Jesús Palá-PaúlJoseph J Brophy
Jan 13, 2006·British Journal of Pharmacology·Moussa B H Youdim, Y S Bakhle
Mar 15, 2006·Journal of Ethnopharmacology·Esra KüpeliErdem Yesilada
Mar 23, 2006·Nature Reviews. Neuroscience·Moussa B H YoudimKeith F Tipton
Aug 28, 2007·Journal of Ethnopharmacology·Michael AdamsMatthias Hamburger
Nov 21, 2007·Journal of Chromatography. a·Jesús Palá-PaúlS Cristina Soria
Jan 8, 2008·Molecular Phylogenetics and Evolution·Carolina I CalviñoStephen R Downie
Nov 17, 2009·Journal of Ethnopharmacology·M KhaderP M Eckl
Nov 3, 2010·Journal of Pharmaceutical and Biomedical Analysis·Carlos CavaleiroJoseph Casanova
Oct 6, 2011·International Review of Neurobiology·John P M Finberg, Ken Gillman
Mar 20, 2012·Journal of Enzyme Inhibition and Medicinal Chemistry·Carolina Dos Santos PassosAmélia Teresinha Henriques
Jan 1, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Barbara ThiemDanuta Kalemba

❮ Previous
Next ❯

Citations

Apr 27, 2017·Toxicological Research·Kyoung Sang ChoIm-Soon Lee
Oct 4, 2018·Phytotherapy Research : PTR·Keylla da Conceição MachadoAna Amelia de Carvalho Melo-Cavalcante
Sep 12, 2020·Nutritional Neuroscience·Elisangela Dos SantosCandida Aparecida Leite Kassuya
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aswir Abd RashedDevi Nair Gunasegavan Rathi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
R PavlinV Vidmar
Drug Design, Development and Therapy
Lesetja J LegoabeJ P Petzer
© 2021 Meta ULC. All rights reserved