The monoamine stabilizer (-)-OSU6162 prevents the alcohol deprivation effect and improves motor impulsive behavior in rats

Addiction Biology
Ida FredrikssonPia Steensland

Abstract

Alcohol craving, in combination with impaired impulse control, often leads to relapse. The dopamine system mediates the rewarding properties of alcohol but is also involved in regulating impulsive behavior. The monoamine stabilizer (-)-OSU6162 (OSU6162) has the ability to stabilize dopamine activity depending on the prevailing dopaminergic tone and may therefore normalize the dopaminergic transmission regulating both alcohol use disorder and impulsivity. We have recently showed that OSU6162 attenuates voluntary alcohol consumption, operant alcohol self-administration, alcohol withdrawal symptoms and cue-induced reinstatement of alcohol seeking in rats. Here, we evaluated OSU6162's effects on motor impulsivity in Wistar rats that had voluntarily consumed alcohol or water for 10 weeks. The five-choice serial reaction time task was used to measure motor impulsivity, and a prolonged waiting period (changed from 5 to 7 seconds) was applied to induce premature responses. OSU6162-testing was conducted twice a week (Tuesdays and Fridays), every other week with regular baseline training sessions in between. We also tested OSU6162's effects on the alcohol deprivation effect in long-term alcohol drinking Wistar rats. The results showed th...Continue Reading

References

Jun 28, 1992·Annals of the New York Academy of Sciences·C P O'BrienR Ehrman
Apr 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Charles J HeyserGeorge F Koob
Feb 18, 2004·Current Medicinal Chemistry·M L CarlssonM Nilsson
Dec 14, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Erkki Tupala, Jari Tiihonen
Jun 1, 2005·Biological Psychology·Chella KamarajanHenri Begleiter
Aug 2, 2005·The American Journal of Psychiatry·Charles P O'Brien
Sep 24, 2005·The Journal of Neuropsychiatry and Clinical Neurosciences·Henrietta Bowden-JonesEileen Joyce
Jun 9, 2006·Addiction Biology·Carla Sanchis-Segura, Rainer Spanagel
Jun 13, 2006·Psychopharmacology·Marcel M van GaalenLouk J M J Vanderschuren
Dec 13, 2006·European Journal of Pharmacology·Philip Seeman, Hong-Chang Guan
Nov 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nora D VolkowChristopher Wong
Mar 4, 2008·British Journal of Pharmacology·V VengelieneR Spanagel
Aug 2, 2008·Alcoholism, Clinical and Experimental Research·Jeffrey A SimmsSelena E Bartlett
Mar 10, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Faïza BenaliouadPierre-Paul Rompré
Jul 28, 2009·Current Drug Abuse Reviews·Michael Soyka, Susanne Rösner
Sep 4, 2009·Psychopharmacology·Andrew J LawrenceLuke Clark
Sep 11, 2009·Addiction Biology·Valentina VengelieneRainer Spanagel
Nov 27, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Naomi A FinebergEric Hollander
May 25, 2010·Alcoholism, Clinical and Experimental Research·C W LejuezHarriet de Wit
Apr 22, 2011·Psychopharmacology·Sophie E WalkerDavid N Stephens
May 1, 2012·Neuroscience·J W Dalley, J P Roiser
May 31, 2014·The American Journal of Psychiatry·Rajesh NarendranW Gordon Frankle
Sep 25, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nelleke TolboomArvid Carlsson
Nov 2, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ida FredrikssonPia Steensland
Oct 21, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Lotfi KhemiriNitya Jayaram-Lindström
Aug 15, 2017·Current Opinion in Psychiatry·Haley Davis, Evelyn Attia

❮ Previous
Next ❯

Citations

Jan 7, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ida FredrikssonYavin Shaham
Oct 20, 2019·Psychopharmacology·Lotfi KhemiriNitya Jayaram-Lindström
Mar 12, 2021·Journal of Neurochemistry·Esi DomiEric Augier

❮ Previous
Next ❯

Software Mentioned

SPSS Statistics
PC IV
5CSRTT
GraphPad Prism
Med

Related Concepts

Related Feeds

Alcohol Use Disorder

Alcohol use disorder involves a pattern of alcohol consumption that includes compulsive use and a loss of control over intake of alcohol. The impact on physical health, socioeconomic factors, and psychiatric health is profound. Find the latest research on alcohol use disorder here.