The monosodium iodoacetate model of osteoarthritis pain in the rat

Methods in Molecular Biology
Cheryl L Marker, James D Pomonis

Abstract

Osteoarthritis (OA) is one form of degenerative joint disease characterized by progressive loss of articular cartilage, decreased function and is frequently accompanied by chronic pain. Given the success of arthroplasty as a treatment for late-stage OA, there is considerable interest in developing therapies pertaining to the management of pain associated with OA as well as therapies designed to slow or reverse the progression of the disease. To this end, establishment of relevant animal models that are amenable to testing novel therapies is of considerable value to the scientific community. Here, we describe a model of OA-related pain in which progressive joint destruction is induced by injection of monosodium iodoacetate into the articular space of the knee of the rat. Further, we describe three different methods to measure pain-related behaviors in this model: hind limb weight bearing, primary mechanical hyperalgesia, and hind limb grip strength.

Citations

Mar 20, 2013·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Kalliopi Lampropoulou-AdamidouNikolaos A Papaioannou
Dec 10, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kelly A KimmerlingKatie C Mowry
Feb 4, 2016·Journal of Orthopaedic Surgery and Research·Emmanuel L KuyinuCato T Laurencin
Feb 18, 2020·Calcified Tissue International·Hasmik Jasmine SamvelyanKatherine Ann Staines
Mar 19, 2013·Annals of the New York Academy of Sciences·Edita NavratilovaFrank Porreca
Jul 5, 2016·Journal of Neuroscience Research·Nicole E BurmaTuan Trang
Apr 4, 2021·Antioxidants·Yohei SanadaShigeru Miyaki
Sep 28, 2020·Neuroscience and Biobehavioral Reviews·Ana Margarida CunhaHugo Leite-Almeida
Apr 22, 2021·Inflammopharmacology·Cleydlenne Costa VasconcelosMaria do Socorro de Sousa Cartágenes

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