The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells

Journal of Neurochemistry
Pascal LaengC Anthony Altar

Abstract

Valproate, an anticonvulsant drug used to treat bipolar disorder, was studied for its ability to promote neurogenesis from embryonic rat cortical or striatal primordial stem cells. Six days of valproate exposure increased by up to fivefold the number and percentage of tubulin beta III-immunopositive neurons, increased neurite outgrowth, and decreased by fivefold the number of astrocytes without changing the number of cells. Valproate also promoted neuronal differentiation in human fetal forebrain stem cell cultures. The neurogenic effects of valproate on rat stem cells exceeded those obtained with the neurotrophins brain-derived growth factor (BDNF) or NT-3, and slightly exceeded the effects obtained with another mood stabilizer, lithium. No effect was observed with carbamazepine. Most of the newly formed neurons were GABAergic, as shown by 10-fold increases in neurons that immunostained for GABA and the GABA-synthesizing enzyme GAD65/67. Double immunostaining for bromodeoxyuridine and tubulin beta III showed that valproate increased by four- to fivefold the proliferation of neuronal progenitors derived from rat stem cells and increased cyclin D2 expression. Valproate also regulated the expression of survival genes, Bad and Bcl...Continue Reading

References

Jun 1, 1990·Journal of the American College of Cardiology·J F Goodwin
Dec 15, 1994·Journal of Neuroscience Research·P LaengG Labourdette
Jun 1, 1996·The American Journal of Psychiatry·C L BowdenD D Morris
Jan 1, 1997·Biological Psychiatry·J C Soares, J J Mann
Apr 24, 1997·Nature·W C DrevetsM E Raichle
Jul 1, 1998·Biological Psychiatry·F M BenesM S Todtenkopf
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M AokiP K Vogt
Mar 11, 2000·The European Journal of Neuroscience·C Vicario-AbejónR D McKay
Jun 23, 2000·Biological Psychiatry·T M MadsenA Tingström
Sep 15, 2000·Journal of Neurochemistry·G ChenH K Manji
Sep 20, 2000·Experimental Neurology·B W ScottW M Burnham
May 1, 2001·Nature Biotechnology·M A CaldwellC N Svendsen
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·K NakashimaT Taga
May 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F M Benes, S Berretta
Feb 28, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·David EngblomAnders Blomqvist
Jul 13, 2002·Biological Psychiatry·Melissa P López-LarsonStephen M Strakowski
Aug 8, 2002·Neuroscience Letters·Roberto B SassiJair C Soares

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Citations

Jan 12, 2007·Experimental Brain Research·Florian A SiebzehnrublIngmar Blumcke
Sep 8, 2007·Cellular and Molecular Neurobiology·Dinesh Lakhanpal, Gurcharan Kaur
Apr 26, 2008·Journal of Molecular Neuroscience : MN·Martin J LanHusseini K Manji
Aug 5, 2008·Journal of Molecular Neuroscience : MN·Thomas K CresonGuang Chen
Feb 26, 2013·The Cerebellum·Ji Young Janice YooDan Goldowitz
Oct 2, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Elisa M YorkA Jane Roskams
Aug 16, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rulun ZhouHusseini K Manji
Oct 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Laetitia AubryAnselme L Perrier
Feb 24, 2009·Journal of Child and Adolescent Psychopharmacology·Kiki ChangAllan Reiss
Nov 29, 2007·Stem Cells and Development·Gabriela G CezarAlysson R Muotri
Aug 27, 2010·Cerebral Cortex·Carlos Sánchez-Huertas, Beatriz Rico
Jun 14, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joseph M BreierTimothy J Shafer
Apr 14, 2006·Current Opinion in Psychiatry·Guang Chen, Husseini K Manji
Aug 12, 2010·Behavioural Pharmacology·Livia PasqualiFrancesco Fornai
Mar 17, 2010·Epilepsy Currents·Chrysanthy Ikonomidou
Jan 10, 2013·Pharmacological Reviews·Chi-Tso ChiuDe-Maw Chuang
Oct 9, 2012·Child and Adolescent Psychiatric Clinics of North America·Manpreet K Singh, Kiki D Chang
Nov 27, 2015·Molecular and Cellular Neurosciences·K Sue O'Shea, Melvin G McInnis
Oct 14, 2011·The American Journal of Geriatric Pharmacotherapy·Fade Mahmoud, Rajesh R Tampi
Jan 5, 2011·Neuroscience and Biobehavioral Reviews·Diane Dufour-RainfrayChristian R Andres
Jul 14, 2010·Neuroscience Letters·Nanchang XieZhaofu Chi
Mar 2, 2010·Molecular and Cellular Neurosciences·Jessica L MacdonaldA Jane Roskams
Oct 15, 2009·Epilepsy Research·Chrysanthy Ikonomidou, Lechoslaw Turski
Sep 22, 2009·Brain Research·Yongchang QianEvelyn Tiffany-Castiglioni
Sep 15, 2009·Brain Research Bulletin·Xiu-Zhen ZhangHong-Yu Zhang
Jun 26, 2009·Progress in Neurobiology·Jessica L MacDonald, A Jane Roskams
Jan 27, 2009·Experimental Neurology·Elena M Vazey, Bronwen Connor
Oct 7, 2008·Epilepsy & Behavior : E&B·Asla Pitkänen, Katarzyna Lukasiuk
Jun 10, 2008·Brain Research Reviews·Konstantinos N FountoulakisConstantin Bouras
Jul 7, 2007·Neuroscience and Biobehavioral Reviews·H Le-NiculescuA B Niculescu

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