The morphine-sparing effect of propacetamol in orthopedic postoperative pain

Journal of Pain and Symptom Management
A Delbos, E Boccard

Abstract

The analgesic efficacy and safety of propacetamol (Pro-Dafalgan), an injectable prodrug of acetaminophen, in combination with morphine administered by patient-controlled analgesia (PCA) were studied in 60 patients (56 men, 4 women; age 18-40 years; mean age, 26 years) after knee ligamentoplasty. Using a double-blind, randomized, parallel-group design, the effects of four (every 6 hr) intravenous injections of 2 g propacetamol (= 1 g acetaminophen) were compared with four injections of placebo (PL) in the recovery room immediately after surgery. Efficacy was assessed over 24 hr by automatic recording on the PCA device of the cumulative dose of morphine and the number of boluses requested. It was also assessed on pain scores rated on a five-point verbal scale and a visual analogue scale before administration, at 1, 2, 3, and 4 hr, and then every 2 hr until the 24th hr after administration. A five-point global efficacy scale was also administered. Any side effects were recorded throughout the duration of the study, and the ability to tolerate the drug was assessed by recording arterial pressure, cardiac and respiratory frequency, and sedation at the same assessment times as the pain scores. The 24-hr morphine consumption was signi...Continue Reading

References

Jan 1, 1992·Fundamental & Clinical Pharmacology·M DepréP J de Schepper
Jul 1, 1992·British Journal of Clinical Pharmacology·B BannwarthA Gaucher
Jan 1, 1992·Current Medical Research and Opinion·W L RoweA J Miller
Jan 1, 1991·Annales Françaises D'anesthèsie Et De Rèanimation·B Dalens
Dec 1, 1986·British Journal of Anaesthesia·H OwenN A Shaw
Nov 14, 1983·The American Journal of Medicine·K J Ivey
Feb 23, 1981·Archives of Internal Medicine·C H Mielke
Jan 1, 1993·European Journal of Clinical Pharmacology·R BjörkmanJ Hedner
May 1, 1993·Surgery, Gynecology & Obstetrics·P A CataldoM J Kilbride

❮ Previous
Next ❯

Citations

May 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D FletcherK Samii
Oct 5, 2006·European Journal of Clinical Pharmacology·E MontanéJ R Laporte
Feb 24, 2011·Archives of Gynecology and Obstetrics·Young-Eun MoonDong-Eon Moon
Apr 4, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Buket TasmaciogluAbdullah Sonsuz
Jun 3, 1999·The Surgical Clinics of North America·R C Etches
Jan 11, 2001·Pharmacology & Therapeutics·R D MacPherson
Sep 29, 1999·Pharmacology & Therapeutics·A R Lloyd-Thomas
Feb 19, 2003·Journal of Pain and Symptom Management·Lowell W ReynoldsKenneth M Verburg
May 28, 2005·European Journal of Anaesthesiology·O FourcadeK Samii
Oct 5, 2006·Current Opinion in Anaesthesiology·P B CoxH Bos
Jun 3, 2009·European Journal of Anaesthesiology·Henning OhnesorgePeter H Tonner
Jan 1, 1996·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·R K Portenoy
Feb 5, 2002·Clinical Pharmacokinetics·Jorn LotschGerd Geisslinger
Aug 21, 2012·Anesthesiology Clinics·Lawrence T LaiAudrée A Bendo
Jun 12, 2010·The Kaohsiung Journal of Medical Sciences·Esad EmirErkan Tomatir
Sep 22, 2007·Anesthesiology Clinics·Jose Ortiz-Cardona, Audrée A Bendo
Feb 17, 2006·Acta Anaesthesiologica Scandinavica·D HynesO Hiesse-Provost
Oct 22, 2005·Current Medical Research and Opinion·Susanne LandwehrSandra Kampe
May 12, 2007·Expert Review of Neurotherapeutics·Yigal LeykinClaudia Ambrosio
Mar 26, 2004·American Journal of Surgery·Adam B SmithUNKNOWN CAPSS-115 Study Group
Mar 13, 2003·Acta Anaesthesiologica Scandinavica·T W HahnM Rasmussen
Apr 12, 2001·European Journal of Anaesthesiology·F AubrunB Riou
Jan 24, 2015·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Shireesh SaurabhIsaac Samuel
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin StocklerDavid Warr

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