The morphological characteristic of the cerebellar cortex in the case of a burning injury

Sudebno-meditsinskaia ekspertiza
Yu E MorozovYu I Pigolkin

Abstract

The objective of the present study was the development of the additional forensic medical criteria for the diagnostics of the intravitality and prescription of the burning injury making use of the morphological changes in the cerebellar cortex. A total of 82 cases of the death from the second- and third a, b-degree flame burns in 63 men and 19 women at the age from 20 to 65 years were available for the analysis. The condition of the cerebellar cortex was evaluated within 0 to 72 hours after the trauma had been inflicted. The routine histological staining technique using hematoxylin and eosin were employed as well as the Nisslin staining carried out in the combination with the immunohistochemical reaction based on the application of the antibodies against the glial fibrillary acidic protein (GFAP). In the case of death during the acute period after the burning injury, the histological study revealed a characteristic complex of the morphological features including the acute swelling of neurons, the increasing expansion of perivascular and pericellular spaces, as swell as hyperoxyphilia of microglia. The astrocytes of cortical II-III layers proved highly sensitive to tissue hypoxia as appears from their reaction with anti-GFAP ant...Continue Reading

References

Jul 19, 2008·Lancet Neurology·Andrew I R MaasRoss Bullock
Oct 16, 2012·Journal of Neuroinflammation·Mahasweta DasShyam S Mohapatra
May 16, 2015·Trends in Neurosciences·Zhihui Yang, Kevin K W Wang
Oct 23, 2015·Cold Spring Harbor Perspectives in Biology·Dwight E Bergles, William D Richardson
Nov 12, 2016·Frontiers in Neuroscience·Kevin J O'Donovan

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