The morphological characteristics of hippocampus and thalamus in mesial temporal lobe epilepsy

BMC Neurology
Dongyan WuWenjing Zheng

Abstract

Mesial temporal lobe epilepsy (MTLE) is the most common form of focal epilepsy, which is frequently characterized by hippocampal sclerosis (HS). Accumulating studies have suggested widespread cortico-cortical connections related to MTLE. The role of subcortical structures involved in general epilepsy has been extensively investigated, but it is still limited in MTLE. Our purpose was to determine the specific morphological correlation between sclerotic hippocampal and thalamic sub-regions, using quantitative analysis, in MTLE. In this study, 23 MTLE patients with unilateral hippocampal sclerosis and 24 healthy controls were examined with three-dimensional T1 MRI. Volume quantitative analysis in the hippocampus and thalamus was conducted and group-related volumetric difference was assessed. Moreover, vertex analysis was further performed using automated software to delineate detailed morphological patterns of the hippocampus and thalamus. The correlation was used to examine whether there is a relationship between volume changes of two subcortical structures and clinical characteristics. The patients had a significant volume decrease in the sclerotic hippocampus (p < 0.001). Compared to controls, obvious atrophic patterns were obs...Continue Reading

References

Feb 26, 2000·Neuropsychologia·Y D Van der WerfJ Jolles
May 18, 2004·Epilepsia·Heinz-Gregor Wieser, UNKNOWN ILAE Commission on Neurosurgery of Epilepsy
Jun 9, 2006·Brain : a Journal of Neurology·Maxime GuyeFabrice Bartolomei
Feb 13, 2008·Epilepsia·Carrie R McDonaldEric Halgren
Dec 30, 2011·Neurology·Boris C BernhardtAndrea Bernasconi
Oct 16, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J SainiP K Pal
Nov 22, 2012·Psychiatry Research·Philipp Arthur ThomannJohannes Schröder
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