The morphology of acute disc herniation: a clinically relevant model defining the role of flexion

Spine
Samuel P VeresNeil D Broom

Abstract

Hydrostatically induced disruption of flexed lumbar intervertebral discs followed by microstructural investigation. To investigate how flexion affects the anulus' ability to resist rupture during hydrostatic loading, and determine how the characteristics of the resulting disc failures compare with those observed clinically. While compression of neutrally positioned motion segments consistently causes vertebral failure, compression of flexed segments can induce herniation. Why flexion has this effect remains unclear. A vast range of herniation characteristics have been documented clinically; whether flexion-related herniations are likely to possess a subset of these is unknown. Forty-two ovine lumbar motion segments, dissected from the same 3 levels of 14 spines, were each flexed 7 degrees or 10 degrees from the neutral position. While maintained at one of these angles, the nucleus of each segment was gradually injected with a viscous radio-opaque gel via an injection screw placed longitudinally within the inferior vertebra, until failure occurred. Each segment was then inspected using microcomputed tomography and oblique illumination microscopy in tandem. RESULTS.: Eighteen segments suffered disc failure; 14 of these were cause...Continue Reading

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Citations

May 4, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Samuel P VeresNeil D Broom
Oct 1, 2010·Topics in Magnetic Resonance Imaging : TMRI·Won C BaeChristine B Chung
Dec 25, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Yun Peng HuangJaap H van Dieën
Dec 30, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Bradley K WeinerJohn A Hipp
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Aug 5, 2014·Journal of Spinal Disorders & Techniques·Kyoung-Tae KimYoung-Baeg Kim
Sep 26, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Cory J LawsJeffrey C Lotz
Apr 17, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Sharon BrownSally Roberts
Jan 3, 2015·The Spine Journal : Official Journal of the North American Spine Society·Samantha A RodriguesNeil D Broom
May 10, 2016·Journal of Biomechanics·Mamiko NoguchiJack P Callaghan
Oct 22, 2016·The Spine Journal : Official Journal of the North American Spine Society·Evgenii BelykhVadim A Byvaltsev
May 18, 2016·Spine·Nikolaus Berger-RoscherHans-Joachim Wilke
Mar 6, 2019·Journal of Biomechanical Engineering·Bo YangGrace O'Connell
Aug 9, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Kelly R WadeNeil D Broom
Feb 20, 2021·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Daniel Viggiani, Jack P Callaghan

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