PMID: 2482623Jan 1, 1989Paper

[The morphology of chemically induced kidney tumors of the rat as a model for the typing of human kidney tumors].

Verhandlungen der Deutschen Gesellschaft für Pathologie
P MeisterH M Rabes

Abstract

1. 109 renal cell carcinomas were produced in 92 Wistar rats by a single dose of 80 mg/kg diethylnitrosamine 4, 16, 24 h after partial liver resection. These tumors showed a wide variety of morphological appearances, comparable with different types of human renal cell carcinomas, as proposed by THOENES et al. in a new cytomorphological classification. However, there were striking differences as to the incidence of the individual tumors types. Whereas clear cell tumor prevailed in human they were very rare in the animal experiment. 2. 54 renal cell carcinomas were produced in 105 rats by a single dose of 30 mg/kg dimethylnitrosamine after a low-protein diet of 5 days. Also in this experiment a variety of different tumor types resulted. Already in early "tubular lesions" a strikingly elevated thymidine labelling was found, in contrast to the surrounding regular tubular epithelial cells. Moreover, topographical relations of various tumor cell types to different segments of the nephron became evident. Besides a fair number of basophilic tumors with transition into proximal tubular epithelial cells, a large number of tumors showing abundant, typically vacuolated cytoplasm became evident. These tumor cells showed in general the highe...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.