The most common chromosome aberration detected by high-resolution comparative genomic hybridization in vulvar intraepithelial neoplasia is not seen in vulvar squamous cell carcinoma

Cytogenetic and Genome Research
T BryndorfC Lundsteen

Abstract

We analyzed genetic changes in condylomas (four cases), vulvar intraepithelial neoplasia I-III (VIN I-III, eleven cases), and primary vulvar squamous cell carcinomas (VSCC, ten cases) by high-resolution comparative genomic hybridization (HR-CGH) and flowcytometry. All samples were also human papilloma virus (HPV)-genotyped. Gain of chromosome 1, the aberration most often seen in VIN III (67%), was not seen in HPV-positive or -negative VSCCs (0%). Both VIN III and VSCC frequently showed gain of 3q (56 and 70%, respectively). The VIN III samples often demonstrated gain of 20q (56%) and 20p (44%), and the VSCC samples gain of 8q (60%), loss of 3p (50%), and 8p (40%). None of the four most frequent changes in the VSCC samples occurred exclusively in the HPV-positive or -negative samples. As expected, we did not find any cytogenetic changes in condylomas and nearly any changes in VIN I-II.

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Citations

Sep 24, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lorenz K ThomasMiriam Reuschenbach
Jun 27, 2017·PloS One·Ellinor ÖstenssonChrister Borgfeldt
Mar 18, 2010·British Journal of Cancer·K J PurdieC M Proby
Jul 22, 2018·Cancer Medicine·Dorian R A SwartsMaaike C G Bleeker
Nov 16, 2005·Clinical Obstetrics and Gynecology·Mario PretiMarc Van Beurden
Jun 24, 2020·International Journal of Cancer. Journal International Du Cancer·Ziena AbdulrahmanMariette I E van Poelgeest

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