The motility-proliferation-metabolism interplay during metastatic invasion

Scientific Reports
Inbal HechtEshel Ben-Jacob

Abstract

Metastasis is the major cause for cancer patients' death, and despite all the recent advances in cancer research it is still mostly incurable. Understanding the mechanisms that are involved in the migration of the cells in a complex environment is a key step towards successful anti-metastatic treatment. Using experimental data-based modeling, we focus on the fundamentals of metastatic invasion: motility, invasion, proliferation and metabolism, and study how they may be combined to maximize the cancer's ability to metastasize. The modeled cells' performance is measured by the number of cells that succeed in migration in a maze, which mimics the extracellular environment. We show that co-existence of different cell clones in the tumor, as often found in experiments, optimizes the invasive ability in a frequently-changing environment. We study the role of metabolism and stimulation by growth factors, and show that metabolism plays a crucial role in the metastatic process and should therefore be targeted for successful treatment.

References

Sep 1, 1995·Immunology Today·J P Girard, T A Springer
Jul 17, 1996·International Journal of Cancer. Journal International Du Cancer·A GieseM E Berens
Sep 27, 2000·Neoplasia : an International Journal for Oncology Research·O KaplanI Tsarfaty
Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Aug 22, 2002·Nature Reviews. Cancer·Jean Paul Thiery
Jan 10, 2003·Journal of Cellular Biochemistry·Yu-Wen Zhang, George F Vande Woude
Jan 25, 2003·Journal of Biochemistry and Molecular Biology·Kyu-Sil ChoiKyu-Won Kim
Apr 3, 2003·Nature Reviews. Cancer·Ruth EtzioniLeland Hartwell
May 2, 2003·Nature Reviews. Cancer·Peter Friedl, Katarina Wolf
Jul 12, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barry Drew, Christiaan Leeuwenburgh
Feb 24, 1956·Science·O WARBURG
Oct 3, 2003·American Journal of Physiology. Cell Physiology·David J MarcinekKevin E Conley
Dec 20, 2003·Nature Reviews. Molecular Cell Biology·Carmen BirchmeierGeorge F Vande Woude
Mar 24, 2004·Current Opinion in Cell Biology·Peter Friedl
Jul 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chong-Feng GaoGeorge F Vande Woude
Oct 26, 2005·Biochemical Society Transactions·M D Brand
Jul 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Muhammad H ZamanPaul Matsudaira
Jun 13, 2008·Journal of Theoretical Biology·Yukio-Pegio GunjiTaichi Haruna
Sep 17, 2008·Cancer Research·Peter Friedl, Katarina Wolf
Jun 16, 2009·Current Opinion in Cell Biology·Tim Lämmermann, Michael Sixt
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Jul 9, 2010·Mathematical Medicine and Biology : a Journal of the IMA·H HatzikirouA Deutsch
Aug 11, 2011·PloS One·Inbal HechtEshel Ben-Jacob
Oct 5, 2011·Neoplasia : an International Journal for Oncology Research·Oltea SampetreanHideyuki Saya
Nov 29, 2011·Cell·Peter Friedl, Stephanie Alexander
Jun 12, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Shin I NishimuraMasaki Sasai
Jan 10, 2013·PLoS Computational Biology·William R Holmes, Leah Edelstein-Keshet
Jun 26, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anjil GiriDenis Wirtz
Jul 26, 2014·Physical Review Letters·S C TakatoriJ F Brady
May 28, 2015·Scientific Reports·Inbal HechtEshel Ben-Jacob
Dec 11, 2007·Soft Matter·Toshiyuki Nakagaki, Robert D Guy

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Citations

Sep 17, 2016·Trends in Cell Biology·Abraham Q Kohrman, David Q Matus
Dec 9, 2016·Omics : a Journal of Integrative Biology·Savita JayaramRavi Sirdeshmukh
Jul 19, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yixuan WangZhenhua Lin
Nov 10, 2017·Molecular Biology of the Cell·Matthew R ZanotelliCynthia A Reinhart-King
Dec 23, 2017·Pathology Oncology Research : POR·G M RobertoMaría Sol Brassesco
Sep 15, 2019·Nature Communications·Matthew R ZanotelliCynthia A Reinhart-King
Jan 25, 2019·Oncology Letters·Xin ChenJun Li
Jun 19, 2018·APL Bioengineering·Kamyar Esmaeili PourfarhangiBojana Gligorijevic
Feb 19, 2019·Frontiers in Biology·Dingcheng GaoSharrell Lee
Mar 27, 2020·OncoTargets and Therapy·Xiaohui DuJungang Xie
Sep 12, 2017·The Journal of Clinical Investigation·M Cecilia CainoDario C Altieri
Jul 30, 2017·Stem Cell Research·Andrea V Cantú, Diana J Laird
Apr 30, 2021·Cell Metabolism·Matthew R ZanotelliCynthia A Reinhart-King
Jun 22, 2021·Frontiers in Genetics·Sergey NikulinAlexander Tonevitsky
May 9, 2021·Biophysical Journal·Abraham Q KohrmanEszter Posfai

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