The motor and cognitive features of Parkinson's disease in patients with concurrent Gaucher disease over 2 years: a case series

Journal of Neurology
Lucy M CollinsRoger A Barker

Abstract

We report the cognitive features and progression of Parkinson's disease (PD) in five patients with concurrent Gaucher disease. The patients presented at an earlier age than patients with sporadic PD, as previously noted by others; but in contrast to many previous reports, our patients followed a variable clinical course. While two patients developed early cognitive deficits and dementia, three others remained cognitively intact over the follow-up period. Thus, in this small case series, PD in the context of GD more closely resembles idiopathic PD in terms of its clinical heterogeneity in contrast to PD associated with GBA heterozygote mutations.

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Citations

Jul 31, 2018·The European Journal of Neuroscience·Julia C GreenlandRoger A Barker
Jun 13, 2019·Current Opinion in Neurology·Emory RyanEllen Sidransky
Jun 6, 2020·Journal of Movement Disorders·Jan O Aasly
Sep 29, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Shani BlumenreichAnthony H Futerman
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Jul 18, 2020·International Journal of Molecular Sciences·Shani BlumenreichAnthony H Futerman
Jun 30, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Stephen MullinAnthony H V Schapira
Oct 16, 2019·Journal of Inherited Metabolic Disease·Reena V KarthaGülin Öz

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