The mouse aquaporin-1 gene

Genomics
C MoonP Agre

Abstract

Members of the aquaporin family of molecular water transporters are expressed in diverse epithelia and in complex developmental patterns. Using a cDNA for mouse Aqp1, the structural gene was isolated and a restriction map was constructed. The 13-kb Aqp1 gene contains four exons with intronic boundaries corresponding to other known aquaporin genes. Transcription begins 67 bp 5' to the translation initiation site and 20 bp 3' from a TATAA consensus sequence. Aqp1 was localized by interspecific mouse backcross mapping to the central region of mouse chromosome 6 syntenic with human chromosome 7p14, where AQP1 had previously been localized. These studies have revealed marked structural similarities between the mouse Aqp1 and the human AQP1 genes, suggesting that further comparative studies may provide molecular insight into genetic regulatory features shared by both species.

Citations

Feb 11, 2016·Journal of Pathology and Translational Medicine·Young Min JoWon Kee Lee
Feb 3, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Masakazu SuzukiShigeyasu Tanaka
Oct 14, 2003·Oncogene·Chulso MoonLi Mao
Feb 24, 2004·American Journal of Hematology·Chulso MoonLi Mao
Mar 23, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kulandaiappan VaradarajRichard T Mathias
Feb 20, 2008·Expert Review of Proteomics·Fulvio MagniMarina Pitto
Mar 15, 2006·World Journal of Gastroenterology : WJG·Shun-Ying JinTong-Hui Ma
Mar 28, 2006·The American Journal of Pathology·Mohammad Obaidul HoqueChulso Moon
Jun 28, 2008·The American Journal of Pathology·Sung Koo KangChulso Moon
Apr 7, 1999·Genomics·G B DownesN A Jenkins
May 20, 1998·Biochemical and Biophysical Research Communications·W JenqG Ramirez
Dec 25, 2007·Biochemical and Biophysical Research Communications·Janghee WooChulso Moon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.