PMID: 9166583Jun 1, 1997Paper

The mouse Cat4 locus maps to chromosome 8 and mutants express lens-corneal adhesion

Mammalian Genome : Official Journal of the International Mammalian Genome Society
J FavorD Stambolian

Abstract

Cat4 is the second largest allelism group in the collection of mouse dominant eye mutations recovered in Neuherberg and carriers express anterior polar cataract, central corneal opacity, and lens-corneal adhesions. We have mapped the Cat4 locus of the mouse to central Chromosome (Chr) 8 at position cM 31. Histological characterization of Cat4(a) heterozygotes and homozygotes indicates failure of separation of the lens vesicle from the surface ectoderm. Human anterior segment ocular dysgenesis (ASOD) is autosomal dominant, carriers express an eye phenotype similar to that of Cat4(a) carriers, and it has been mapped to a region of 4q homologous to mouse central Chr 8. Thus, on the basis of phenotype and map position, Cat4 may be a mouse model of human ASOD. The genes Junb, Jund1, Mel, and Zfp42 are discussed as possible candidates for Cat4.

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Citations

May 10, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Larissa WakefieldEdith Sim
Dec 25, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Michael RosemannJochen Graw
Feb 5, 1999·Progress in Retinal and Eye Research·J Graw
Jan 11, 2000·Eye·J Graw
Jan 22, 2010·Journal of Genetics·Jochen Graw
Jan 29, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Giuseppe F PontorieroJudith A West-Mays

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